Repozytorium Uniwersytetu Jagiellońskiego

Elemental anomalies in the hippocampal formation after repetitive electrical stimulation : an X-ray fluorescence microscopy study

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dc.contributor.author

Chwiej, Joanna

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Gabryś, Hubert

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Janeczko, Krzysztof [SAP11008688]

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Kutorasińska, Justyna

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Gzieło-Jurek, Kinga [SAP14002533]

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Matusiak, Katarzyna

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Appel, Karen

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Setkowicz, Zuzanna [SAP11017135]

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dc.date.accessioned

2015-03-31T10:07:17Z

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2015-03-31T10:07:17Z

dc.date.issued

2014

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dc.identifier.issn

0949-8257

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dc.identifier.uri

http://ruj.uj.edu.pl/xmlui/handle/item/4403

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eng

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dc.title

Elemental anomalies in the hippocampal formation after repetitive electrical stimulation : an X-ray fluorescence microscopy study

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dc.type

JournalArticle

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dc.description.physical

1209-1220

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dc.description.additional

Bibliogr. s. 1219-1220

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dc.abstract.other

Our previous studies carried out on the pilocarpine model of seizures showed that highly resolved elemental analysis might be very helpful in the investigation of processes involved in the pathogenesis of epilepsy, such as excitotoxicity or mossy fiber sprouting. In this study, the changes in elemental composition that occurred in the hippocampal formation in the electrical kindling model of seizures were examined to determine the mechanisms responsible for the phenomenon of kindling and spontaneous seizure activity that may occur in this animal model. X-ray fluorescence microscopy was applied for topographic and quantitative analysis of selected elements in tissues taken from rats subjected to repetitive transauricular electroshocks (ES) and controls (N). The detailed comparisons were carried out for sectors 1 and 3 of the Ammon's horn (CA1 and CA3, respectively), the dentate gyrus (DG) and hilus of DG. The obtained results showed only one statistically significant difference between ES and N groups, namely a higher level of Fe was noticed in CA3 region in the kindled animals. However, further analysis of correlations between the elemental levels and quantitative parameters describing electroshock-induced tonic and clonic seizures showed that the areal densities of some elements (Ca, Cu, Zn) strongly depended on the progress of kindling process. The areal density of Cu in CA1 decreased with the cumulative (totaled over 21 stimulation days) intensity and duration of electroshock-induced tonic seizures while Zn level in the hilus of DG was positively correlated with the duration and intensity of both tonic and clonic seizures.

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rat kindling model of epilepsy

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transauricural electroshocks

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topographic and quantitative elemental analysis

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X-ray fluorescence microscopy

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synchrotron radiation

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dc.description.volume

19

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dc.description.number

7

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dc.identifier.doi

10.1007/s00775-014-1177-7

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dc.identifier.eissn

1432-1327

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dc.title.journal

JBIC Journal of Biological Inorganic Chemistry

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dc.language.container

eng

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dc.affiliation

Wydział Biologii i Nauk o Ziemi : Instytut Zoologii

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Article

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dc.rights.original

CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0;

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.pointsMNiSW

[2014 A]: 30



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