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Elemental anomalies in the hippocampal formation after repetitive electrical stimulation : an X-ray fluorescence microscopy study

Elemental anomalies in the hippocampal formation ...

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dc.contributor.author Chwiej, Joanna pl
dc.contributor.author Gabryś, Hubert pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.contributor.author Kutorasińska, Justyna pl
dc.contributor.author Gzieło, Kinga [SAP14002533] pl
dc.contributor.author Matusiak, Katarzyna pl
dc.contributor.author Appel, Karen pl
dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.date.accessioned 2015-03-31T10:07:17Z
dc.date.available 2015-03-31T10:07:17Z
dc.date.issued 2014 pl
dc.identifier.issn 0949-8257 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/4403
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Elemental anomalies in the hippocampal formation after repetitive electrical stimulation : an X-ray fluorescence microscopy study pl
dc.type JournalArticle pl
dc.description.physical 1209-1220 pl
dc.description.additional Bibliogr. s. 1219-1220. Zuzanna Setkowicz-Janeczko podpisana nazwiskiem Setkowicz, Kinga Gzieło podpisana nazwiskiem Gzieło-Jurek pl
dc.abstract.other Our previous studies carried out on the pilocarpine model of seizures showed that highly resolved elemental analysis might be very helpful in the investigation of processes involved in the pathogenesis of epilepsy, such as excitotoxicity or mossy fiber sprouting. In this study, the changes in elemental composition that occurred in the hippocampal formation in the electrical kindling model of seizures were examined to determine the mechanisms responsible for the phenomenon of kindling and spontaneous seizure activity that may occur in this animal model. X-ray fluorescence microscopy was applied for topographic and quantitative analysis of selected elements in tissues taken from rats subjected to repetitive transauricular electroshocks (ES) and controls (N). The detailed comparisons were carried out for sectors 1 and 3 of the Ammon's horn (CA1 and CA3, respectively), the dentate gyrus (DG) and hilus of DG. The obtained results showed only one statistically significant difference between ES and N groups, namely a higher level of Fe was noticed in CA3 region in the kindled animals. However, further analysis of correlations between the elemental levels and quantitative parameters describing electroshock-induced tonic and clonic seizures showed that the areal densities of some elements (Ca, Cu, Zn) strongly depended on the progress of kindling process. The areal density of Cu in CA1 decreased with the cumulative (totaled over 21 stimulation days) intensity and duration of electroshock-induced tonic seizures while Zn level in the hilus of DG was positively correlated with the duration and intensity of both tonic and clonic seizures. pl
dc.subject.en rat kindling model of epilepsy pl
dc.subject.en transauricural electroshocks pl
dc.subject.en topographic and quantitative elemental analysis pl
dc.subject.en X-ray fluorescence microscopy pl
dc.subject.en synchrotron radiation pl
dc.description.volume 19 pl
dc.description.number 7 pl
dc.identifier.doi 10.1007/s00775-014-1177-7 pl
dc.identifier.eissn 1432-1327 pl
dc.title.journal JBIC. Journal of Biological Inorganic Chemistry pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
.pointsMNiSW [2014 A]: 30

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