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Proton magnetic resonance spectroscopy of periventricular white matter and hippocampus in obstructive sleep apnea patients

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Proton magnetic resonance spectroscopy of periventricular white matter and hippocampus in obstructive sleep apnea patients

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dc.contributor.author Kızılgöz, Volkan pl
dc.contributor.author Aydın, Hasan pl
dc.contributor.author Tatar, İdil Güneş pl
dc.contributor.author Hekimoğlu, Baki pl
dc.contributor.author Ardıç, Sadık pl
dc.contributor.author Fırat, Hikmet pl
dc.contributor.author Dönmez, Cem pl
dc.date.accessioned 2017-09-05T09:23:56Z
dc.date.available 2017-09-05T09:23:56Z
dc.date.issued 2013 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/43831
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode *
dc.title Proton magnetic resonance spectroscopy of periventricular white matter and hippocampus in obstructive sleep apnea patients pl
dc.type JournalArticle pl
dc.description.physical 7-14 pl
dc.description.additional Bibliogr. s. 13-14 pl
dc.abstract.en Background: The purpose of this study was to diagnose the hypoxic impairment by Magnetic resonance spectroscopy (MRS), an advanced MR imaging technique, which could not be visualised by routine imaging methods in patients with obstructive sleep apnea (OSA). Material/Methods: 20 OSA patients and 5 controls were included in this prospective research. MRS was performed on these 25 subjects to examine cerebral hypoxemia in specific regions (periventricular white matter and both hippocampi). Polysomnography was assumed as the gold standard. Statistical analysis was assessed by Mann-Whitney U test and Receiver operating characteristics (ROC) curve for NAA/Cho, NAA/Cr and Cho/Cr ratios. Results: In the periventricular white matter, NAA/Cho ratio in OSA patients was significantly lower than in the control group (p<0.05). There were no statistical differences between the OSA and the control group for NAA/Cho, NAA/Cr and Cho/Cr ratios for both hippocampal regions. Additionally, Cho/Cr ratio in the periventricular white matter region of OSA group was higher than in the control group (p<0.05). Conclusions: Hypoxic impairment induced by repeated episodes of apnea leads to significant neuronal damage in OSA patients. MRS provides valuable information in the assessment of hypoxic ischemic impairment by revealing important metabolite ratios for the specific areas of the brain. pl
dc.subject.en magnetic resonance spectroscopy pl
dc.subject.en sleep apnea syndromes pl
dc.subject.en magnetic resonance pl
dc.subject.en sleep disorders pl
dc.subject.en polysomnography pl
dc.description.volume 78 pl
dc.description.number 4 pl
dc.identifier.doi 10.12659/PJR.889923 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska