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Evaluation of usefulness of scintigraphic imaging in diagnosis of intrathecal drug delivery system malfunction : a preliminary report

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Evaluation of usefulness of scintigraphic imaging in diagnosis of intrathecal drug delivery system malfunction : a preliminary report

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dc.contributor.author Teodorczyk, Jacek pl
dc.contributor.author Szmuda, Tomasz pl
dc.contributor.author Siemiński, Mariusz pl
dc.contributor.author Lass, Piotr pl
dc.contributor.author Słoniewski, Paweł pl
dc.date.accessioned 2017-09-05T08:01:22Z
dc.date.available 2017-09-05T08:01:22Z
dc.date.issued 2013 pl
dc.identifier.issn 1733-134X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/43817
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/pl/legalcode *
dc.title Evaluation of usefulness of scintigraphic imaging in diagnosis of intrathecal drug delivery system malfunction : a preliminary report pl
dc.type JournalArticle pl
dc.description.physical 21-27 pl
dc.description.additional Bibliogr. s. 27 pl
dc.abstract.en Background: Implantable intrathecal drug delivery systems (IDDS) are basic tool enabling chronic intrathecal pharmacotherapy. Lack of expected clinical results of IDDS therapy necessitates search for the cause with the help of diagnostic imaging methods among other things. Beside radiological techniques, it is also possible to visually assess IDDS systems by nuclear medicine methods. In this study we assess utility of radioisotopic methods in differential diagnosis of failure of therapy with IDDS systems. Material/Methods: Scintigraphic studies were performed in selected patients with neurological diseases associated with spasticity, who had IDDS system implanted and were unable to maintain satisfying clinical effect of inrathecally infused baclofen. After emptying the IDDS system of the drug, radiotracer (99mTc-DTPA) solution was injected into the pump reservoir. Subsequently, a series of scintigraphic images was registered, demonstrating passage and distribution of the infused radiotracer. Results: In all investigated cases, scintigraphic study resulted in acquiring relevant additional diagnostic information. Normal or disrupted distribution of radiotracer in spinal canal allowed for a diagnosis drug resistance or demonstrated presence of arachnoid adhesions respectively. Early appearance of radiotracer in blood was considered a proof of leak. Our examinations had decisive influence on further patient treatment, allowing for diagnosis of drug resistance in one patient or complication related to IDDS system in three other cases including breakage of a catheter, pump malfunction and arachnoid adhesions. Conclusions: Scintigraphic methods carry significant amount of information facilitating final diagnosis of the cause of IDDS therapy failure. They should become an important element complementing the diagnostic strategy in patients with suspected failure of intrathecal drug administration systems. Interpretation of radioisotopic studies, since they are purely functional, must be performed in strict relation to clinical data and radiological examinations as they carry indispensable, basic information regarding morphology. pl
dc.subject.en intrathecal drug delivery system pl
dc.subject.en intrathecal baclofen pl
dc.subject.en intrathecal pl
dc.subject.en baclofen pl
dc.subject.en scintigraphy pl
dc.subject.en 99mTc-DTPA pl
dc.description.volume 78 pl
dc.description.number 3 pl
dc.identifier.doi 10.12659/PJR.889130 pl
dc.identifier.eissn 1899-0967 pl
dc.title.journal Polish Journal of Radiology pl
dc.language.container eng pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 3.0 Polska