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Determining protein similarity by comparing hydrophobic core structure

Determining protein similarity by comparing hydrophobic ...

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dc.contributor.author Gadzała, M. pl
dc.contributor.author Kalinowska, Barbara [USOS61115] pl
dc.contributor.author Banach, Mateusz [SAP20011078] pl
dc.contributor.author Konieczny, Leszek pl
dc.contributor.author Roterman-Konieczna, Irena [SAP12018592] pl
dc.date.accessioned 2017-07-06T09:28:50Z
dc.date.available 2017-07-06T09:28:50Z
dc.date.issued 2017 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/42433
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Determining protein similarity by comparing hydrophobic core structure pl
dc.type JournalArticle pl
dc.abstract.en Formal assessment of structural similarity is − next to protein structure prediction − arguably the most important unsolved problem in proteomics. In this paper we propose a similarity criterion based on commonalities between the proteins’ hydrophobic cores. The hydrophobic core emerges as a result of conformational changes through which each residue reaches its intended position in the protein body. A quantitative criterion based on this phenomenon has been proposed in the framework of the CASP challenge. The structure of the hydrophobic core − including the placement and scope of any deviations from the idealized model − may indirectly point to areas of importance from the point of view of the protein’s biological function. Our analysis focuses on an arbitrarily selected target from the CASP11 challenge. The proposed measure, while compliant with CASP criteria (70–80% correlation), involves certain adjustments which acknowledge the presence of factors other than simple spatial arrangement of solids. pl
dc.subject.en biological sciences pl
dc.subject.en bioinformatics pl
dc.description.volume 3 pl
dc.description.number 2 pl
dc.identifier.doi 10.1016/j.heliyon.2017.e00235 pl
dc.identifier.eissn 2405-8440 pl
dc.title.journal Heliyon pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Zakład Bioinformatyki i Telemedycyny pl
dc.affiliation Wydział Fizyki, Astronomii i Informatyki Stosowanej : Zakład Technologii Informatycznych pl
dc.subtype Article pl
dc.identifier.articleid e00235 pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl

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