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The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brain

The proliferative response of S-100 protein-positive ...

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dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2015-03-12T09:38:07Z
dc.date.available 2015-03-12T09:38:07Z
dc.date.issued 1991 pl
dc.identifier.issn 0006-8993 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/3765
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title The proliferative response of S-100 protein-positive glial cells to injury in the neonatal rat brain pl
dc.type JournalArticle pl
dc.description.physical 86-90 pl
dc.abstract.other Astroglial proliferative response to unilateral injury of the cerebral hemisphere was studied in newborn rats using [H-3]thymidine autoradiography combined with immunocytochemical staining for S-100 protein as an astroglial marker. The animals received [H-3]thymidine at different intervals following injury and the distribution of double-labeled cells was recorded 4 h after each [H-3]thymidine injection. The reactive proliferation of all cells within the investigated areas was detectable as early as about 2 h after injury. However, the quantitative increase in astroglial mitotic rate could be first detected on day 1 following the injury and the reactive changes were observed until day 8. They were regarded as evidence for the ability of astroglia to proliferate in response to injury in the neonatal brain. Since the astroglial divisions occurred mainly at the lesion site, the post-traumatic gliosis could be considered not only a result of astrocyte migration towards the lesion but also an effect of local mitotic activity. pl
dc.subject.en brain injury pl
dc.subject.en reactive astrocyte proliferation pl
dc.subject.en newborn rat pl
dc.subject.en S-100 protein immunocytochemistry pl
dc.subject.en autoradiography pl
dc.description.volume 564 pl
dc.description.number 1 pl
dc.identifier.doi 10.1016/0006-8993(91)91355-5 pl
dc.identifier.eissn 1872-6240 pl
dc.title.journal Brain Research pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl


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