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Respiration phase-locks to fast stimulus presentations : implications for the interpretation of posterior midline "deactivations"
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Respiration phase-locks to fast stimulus presentations : implications for the interpretation of posterior midline "deactivations"
Bibliographic description
| title: | Respiration phase-locks to fast stimulus presentations : implications for the interpretation of posterior midline "deactivations" |
| author: | Huijbers Willem, Pennartz Cyriel M. A., Beldzik Ewa  , Domagalik-Pittner Aleksandra , Vinck M., Hofman Winnie F., Cabeza Roberto, Daselaar Sander M. |
| journal title: | Human Brain Mapping |
| volume: | 35 |
| issue: | 9 |
| date of publication : | 2014 |
| pages: | 4932-4943 |
| ISSN: |
1065-9471 |
| eISSN: |
1097-0193 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | The posterior midline region (PMR)-considered a core of the default mode network-is deactivated during successful performance in different cognitive tasks. The extent of PMR-deactivations is correlated with task-demands and associated with successful performance in various cognitive domains. In the domain of episodic memory, functional MRI (fMRI) studies found that PMR-deactivations reliably predict learning (successful encoding). Yet it is unclear what explains this relation. One intriguing possibility is that PMR-deactivations are partially mediated by respiratory artifacts. There is evidence that the fMRI signal in PMR is particularly prone to respiratory artifacts, because of its large surrounding blood vessels. As respiratory fluctuations have been shown to track changes in attention, it is critical for the general interpretation of fMRI results to clarify the relation between respiratory fluctuations, cognitive performance, and fMRI signal. Here, we investigated this issue by measuring respiration during word encoding, together with a breath-holding condition during fMRI-scanning. Stimulus-locked respiratory analyses showed that respiratory fluctuations predicted successful encoding via a respiratory phase-locking mechanism. At the same time, the fMRI analyses showed that PMR-deactivations associated with learning were reduced during breath-holding and correlated with individual differences in the respiratory phase-locking effect during normal breathing. A left frontal region-used as a control region-did not show these effects. These findings indicate that respiration is a critical factor in explaining the link between PMR-deactivation and successful cognitive performance. Further research is necessary to demonstrate whether our findings are restricted to episodic memory encoding, or also extend to other cognitive domains. |
| affiliation: | Pion Prorektora ds. badań naukowych i funduszy strukturalnych : Małopolskie Centrum Biotechnologii |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
