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Endocannabinoid and cannabinoid-like fatty acid amide levels correlate with pain-related symptoms in patients with IBS-D and IBS-C : a pilot study

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Endocannabinoid and cannabinoid-like fatty acid amide levels correlate with pain-related symptoms in patients with IBS-D and IBS-C : a pilot study

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dc.contributor.author Fichna, Jakub pl
dc.contributor.author Wood, JodiAnne pl
dc.contributor.author Papanastasiou, Malvina pl
dc.contributor.author Vadivel, Subramanian K. pl
dc.contributor.author Oprocha, Piotr pl
dc.contributor.author Sałaga, Maciej pl
dc.contributor.author Sobczak, Marta pl
dc.contributor.author Mokrowiecka, Anna pl
dc.contributor.author Cygankiewicz, Adam I. pl
dc.contributor.author Zakrzewski, Piotr K. pl
dc.contributor.author Małecka-Panas, Ewa pl
dc.contributor.author Krajewska, Wanda M. pl
dc.contributor.author Kościelniak, Piotr [SAP11018366] pl
dc.contributor.author Makriyannis, Alexandros pl
dc.contributor.author Storr, Martin A. pl
dc.date.accessioned 2014-07-15T05:35:45Z
dc.date.available 2014-07-15T05:35:45Z
dc.date.issued 2013 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/35
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 3.0 Polska *
dc.rights.uri http://creativecommons.org/licenses/by/3.0/pl/legalcode *
dc.title Endocannabinoid and cannabinoid-like fatty acid amide levels correlate with pain-related symptoms in patients with IBS-D and IBS-C : a pilot study pl
dc.type JournalArticle pl
dc.abstract.en Aims Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder, associated with alterations of bowel function, abdominal pain and other symptoms related to the GI tract. Recently the endogenous cannabinoid system (ECS) was shown to be involved in the physiological and pathophysiological control of the GI function. The aim of this pilot study was to investigate whether IBS defining symptoms correlate with changes in endocannabinoids or cannabinoid like fatty acid levels in IBS patients. Methods AEA, 2-AG, OEA and PEA plasma levels were determined in diarrhoea-predominant (IBS-D) and constipation-predominant (IBS-C) patients and were compared to healthy subjects, following the establishment of correlations between biolipid contents and disease symptoms. FAAH mRNA levels were evaluated in colonic biopsies from IBS-D and IBS-C patients and matched controls. Results Patients with IBS-D had higher levels of 2AG and lower levels of OEA and PEA. In contrast, patients with IBS-C had higher levels of OEA. Multivariate analysis found that lower PEA levels are associated with cramping abdominal pain. FAAH mRNA levels were lower in patients with IBS-C. Conclusion IBS subtypes and their symptoms show distinct alterations of endocannabinoid and endocannabinoid-like fatty acid levels. These changes may partially result from reduced FAAH expression. The here reported changes support the notion that the ECS is involved in the pathophysiology of IBS and the development of IBS symptoms. pl
dc.description.volume 8 pl
dc.description.number 12 pl
dc.identifier.doi 10.1371/journal.pone.0085073 pl
dc.identifier.eissn 1932-6203 pl
dc.title.journal PLoS ONE pl
dc.language.container eng pl
dc.affiliation Wydział Matematyki i Informatyki : Instytut Matematyki pl
dc.subtype Article pl
dc.identifier.articleid e85073 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
.pointsMNiSW [2013 A]: 40


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Udzielam licencji. Uznanie autorstwa 3.0 Polska Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 3.0 Polska