Jagiellonian University Repository

Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides

pcg.skipToMenu

Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides

Show full item record

dc.contributor.author Ciszek-Lenda, Marta [SAP20008509] pl
dc.contributor.author Strus, Magdalena [SAP20008032] pl
dc.contributor.author Górska-Frączek, Sabina pl
dc.contributor.author Targosz-Korecka, Marta [SAP11019208] pl
dc.contributor.author Śróttek, Małgorzata [SAP20006078] pl
dc.contributor.author Heczko, Piotr [SAP20000595] pl
dc.contributor.author Gamian, Andrzej pl
dc.contributor.author Szymoński, Marek [SAP11006649] pl
dc.contributor.author Marcinkiewicz, Janusz [SAP20000603] pl
dc.date.accessioned 2017-01-03T13:51:06Z
dc.date.available 2017-01-03T13:51:06Z
dc.date.issued 2011 pl
dc.identifier.issn 1426-3912 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/34835
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/pl/legalcode *
dc.title Strain specific immunostimulatory potential of lactobacilli-derived exopolysaccharides pl
dc.type JournalArticle pl
dc.description.physical 121-129 pl
dc.identifier.weblink http://www.termedia.pl/-Experimental-immunology-Strain-specific-immunostimulatory-potential-of-lactobacilli-derived-exopolysaccharides,10,17497,1,1.html pl
dc.abstract.en Lactobacilli, the most commonly used probiotics, show strain specific immunostimulatory effects. The strain specificity is related to the structure of cell-wall components such as lipoteichoic acids (LTAs), ligands for TLR2. In contrast, the role of exopolysaccharides (EPSs), the major components of lactobacilli biofilm, in the “cross-talk” between bacteria and the immune system is poorly documented. In this study, we have tested immunomodulating potential of lactobacilli derived EPSs, by their ability to modulate in vitro production of cytokines by murine peritoneal macrophages. We have examined EPSs of three lactobacilli strains (L. reuteri, L. johnsonii, L. animalis/murinus) isolated from colitic mice. The effect was compared with that of whole bacteria and LTA. All three nonviable Lactobacillus strains induced high amounts of cytokines with a strain specific profile. In contrast, the tested exopolysaccharides, exert low, albeit highly strain diversified stimulatory activities. The immunostimulatory potential of EPSs was correlated with the interaction strength between EPS and macrophage receptors as measured by atomic force spectroscopy. pl
dc.subject.en cytokines pl
dc.subject.en macrophages pl
dc.subject.en lipoteichoic acid (LTA) pl
dc.subject.en exopolysaccharide (EPS) pl
dc.subject.en probiotics pl
dc.subject.en lactobacilli pl
dc.description.volume 36 pl
dc.description.number 3 pl
dc.identifier.eissn 1644-4124 pl
dc.title.journal Central-European Journal of Immunology pl
dc.language.container eng pl
dc.date.accession 2017-01-03 pl
dc.affiliation Wydział Lekarski : Zakład Immunologii pl
dc.affiliation Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego pl
dc.affiliation Wydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologii pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / OP pl
.pointsMNiSW [2011 A]: 15


Files in this item

This item appears in the following Collection(s)

Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa