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Influence of the aqueous environment on protein structure : a plausible hypothesis concerning the mechanism of amyloidogenesis
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Influence of the aqueous environment on protein structure : a plausible hypothesis concerning the mechanism of amyloidogenesis
Bibliographic description
| title: | Influence of the aqueous environment on protein structure : a plausible hypothesis concerning the mechanism of amyloidogenesis |
| author: | Roterman-Konieczna Irena  , Banach Mateusz , Kalinowska Barbara , Konieczny Leszek |
| journal title: | Entropy |
| volume: | 18 |
| issue: | 10 |
| date of publication : | 2016 |
| article ID: | 351 |
| eISSN: |
1099-4300 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | The aqueous environment is a pervasive factor which, in many ways, determines the protein folding process and consequently the activity of proteins. Proteins are unable to perform their function unless immersed in water (membrane proteins excluded from this statement). Tertiary conformational stabilization is dependent on the presence of internal force fields (nonbonding interactions between atoms), as well as an external force field generated by water. The hitherto the unknown structuralization of water as the aqueous environment may be elucidated by analyzing its effects on protein structure and function. Our study is based on the fuzzy oil drop model—a mechanism which describes the formation of a hydrophobic core and attempts to explain the emergence of amyloid-like fibrils. A set of proteins which vary with respect to their fuzzy oil drop status (including titin, transthyretin and a prion protein) have been selected for in-depth analysis to suggest the plausible mechanism of amyloidogenesis. |
| keywords in English: | amyloid, bioinformatics, divergence entropy, hydrophobic core, prion, titin, transthyretin |
| departmental parameterization: | 30 |
| affiliation: | Wydział Fizyki, Astronomii i Informatyki Stosowanej, Wydział Lekarski : Zakład Bioinformatyki i Telemedycyny |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
