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IgA Antiphospholipid Antibodies and Anti-Domain 1 of Beta 2 Glycoprotein 1 Antibodies are Associated with Livedo Reticularis and Heart Valve Disease in Antiphospholipid Syndrome

IgA Antiphospholipid Antibodies and Anti-Domain 1 ...

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dc.contributor.author Cieśla, Marek pl
dc.contributor.author Wypasek, Ewa [SAP20008847] pl
dc.contributor.author Undas, Anetta [SAP20001686] pl
dc.date.accessioned 2015-02-27T09:56:06Z
dc.date.available 2015-02-27T09:56:06Z
dc.date.created 2014 pl
dc.date.issued 2014 pl
dc.identifier.issn 1230-025X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/3371
dc.language eng pl
dc.title IgA Antiphospholipid Antibodies and Anti-Domain 1 of Beta 2 Glycoprotein 1 Antibodies are Associated with Livedo Reticularis and Heart Valve Disease in Antiphospholipid Syndrome pl
dc.type JournalArticle pl
dc.description.physical 729–733 pl
dc.identifier.weblink http://www.advances.am.wroc.pl/ pl
dc.abstract.en Background. Antiphospholipid syndrome (APS) is an autoimmune disease associated with venous or arterial thrombosis and pregnancy loss, but also infrequently with non-criteria APS manifestations such as thrombocytopenia, livedo reticularis and heart valve disease. The occurrence of antiphospholipid antibodies is necessary to diagnose APS and includes the presence of lupus anticoagulant and anticardiolipin as well as anti-β2-glycoprotein I antibodies, both in IgM and/or IgG isotype. Objectives. The aim of this study was to evaluate the associations between antiphospholipid antibodies including IgA isotype and IgG anti-domain I of β2-glycoprotein I (β-2GPI-D1) and non-criteria-related manifestations of APS. Material and Methods. Thirty-three consecutive APS patients (26 women, 7 men, aged 44.1 ± 15 years), including 23 (69.7%) subjects with primary APS, were enrolled. Together with standard antiphospholipid antibodies, IgA anticardiolipin, IgA anti-β2-glycoprotein I and IgG anti-β-2GPI-D1 antibodies in serum samples were evaluated by chemiluminescence using the QUANTA Flash® System. Results. Livedo reticularis (n = 8, 24.2%) was associated with increased levels of IgG anti-β-2GPI-D1 (p = 0.005), IgA anticardiolipin (p = 0.001) and IgA anti-β2-glycoprotein I (p = 0.002) antibodies. Heart valve disease (n = 9, 27.3%) was observed in patients with higher IgG anti-β-2GPI-D1 (p = 0.01). The associations of HVD with increased levels of IgA aCL and IgA anti-β-2GPI tended to be significant (p = 0.07). None of antiphospholipid antibodies showed association with thrombocytopenia (n = 6, 18.2%). Conclusions. Our study suggests that increased IgA antiphospholipid antibodies and IgG anti-β-2GPI-D1 antibodies may be involved in the development of livedo reticularis and heart valve disease in APS patients. pl
dc.subject.en antiphospholipid syndrome pl
dc.subject.en beta 2 glycoprotein 1 pl
dc.subject.en domain 1 pl
dc.subject.en heart valve disease pl
dc.subject.en livedo reticularis pl
dc.description.volume 23 pl
dc.description.number 5 pl
dc.identifier.eissn 1899–5276 pl
dc.title.journal Advances in Clinical and Experimental Medicine pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Instytut Kardiologii pl
dc.subtype Article pl


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