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Intralesional injection of interferon gamma affects reactive proliferation of astrocytes in the neonatal rat brain : a preliminary study of the age-dependent effect

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Intralesional injection of interferon gamma affects reactive proliferation of astrocytes in the neonatal rat brain : a preliminary study of the age-dependent effect

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dc.contributor.author Pawliński, Rafał pl
dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.contributor.author Ziaja, Marek [SAP11015503] pl
dc.contributor.author Sołtys, Zbigniew [SAP11012054] pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-10-28T10:42:18Z
dc.date.available 2016-10-28T10:42:18Z
dc.date.issued 1999 pl
dc.identifier.issn 0239-8508 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/31865
dc.language eng pl
dc.title Intralesional injection of interferon gamma affects reactive proliferation of astrocytes in the neonatal rat brain : a preliminary study of the age-dependent effect pl
dc.type JournalArticle pl
dc.description.physical 237-242 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana nazwiskiem Setkowicz pl
dc.abstract.en Following a mechanical lesion of the left cerebral hemisphere, newborn male rats received a single injection of recombinant rat interferon gamma (IFN gamma) into the lesion cavity at doses of 5, 50 and 500 U. One or two days after the injury the rats were injected with H-3-thymidine. Brain sections were immunostained for glial fibrillary acidic protein (GFAP), subjected to autoradiography and examined microscopically to record proliferating GFAP-immunopositive (GFAP+) astrocytes labeled with H-3-thymidine. Following the intermediate 50 U dose of IFN gamma, numbers of GFAP+ astrocytes and of their mitoses on day 1 after injury were significantly higher than in controls. Nevertheless, the astrocyte labeling index remained at the control level. Injections of the minimal 5 U or the maximal 500 U doses of IFN gamma had no effect on that day. On day 2, however, each of the three doses evoked a statistically significant but dose-independent reduction of the labeling index without similar changes in total number of GFAP+ astrocytes or in numbers of their divisions. The changes appear to indicate a non-linear relation between the intensity of reactive behaviour of astrocytes and the amount of IFN gamma injected into the lesion area. On the basis of previous publications, IFN gamma effects on the astrocyte reactivity are discussed as being age-dependent. pl
dc.description.volume 37 pl
dc.description.number 4 pl
dc.identifier.eissn 1897-5631 pl
dc.title.journal Folia Histochemica et Cytobiologica pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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