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Tacrolimus (FK506) and cyclosporin A reduce macrophage recruitment to the rat brain injured at perinatal and early postnatal periods

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Tacrolimus (FK506) and cyclosporin A reduce macrophage recruitment to the rat brain injured at perinatal and early postnatal periods

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dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.contributor.author Caryk, Maria pl
dc.contributor.author Szafraniec, Milena [SAP14014477] pl
dc.contributor.author Żmudzińska, Anna pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-10-28T10:36:02Z
dc.date.available 2016-10-28T10:36:02Z
dc.date.issued 2009 pl
dc.identifier.issn 0161-6412 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/31864
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Tacrolimus (FK506) and cyclosporin A reduce macrophage recruitment to the rat brain injured at perinatal and early postnatal periods pl
dc.type JournalArticle pl
dc.description.physical 1060-1067 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz pl
dc.abstract.en Objective: Tacrolimus (FK506) and cyclosporin A (CsA), immunosuppressants widely used in post-transplantional therapy, have been reported to protect neurons in the injured brain. This effect can be exerted directly and indirectly via inflammatory cells. Since the data come exclusively from studies on the adult brain, we examined effects of the drugs on the macrophage recruitment in the brain injured at early developmental stages. Methods: Following the brain injury, 1- and 6-day-old Wistar rats (P1s and P6s, respectively) were treated with FK506 or CsA and injected with [3 H] thymidine. Brain sections were processed for BSI-B4 isolectin histochemistry and subjected to autoradiography to visualize proliferating and non-proliferating macrophages. Results: In P1s (n = 33), FK506 evoked a dose-dependent reduction in the number of macrophages. P6s (n = 30) presented greater decreases in macrophage numbers and their proliferative activity than the newborns. CsA application in P1s (n = 27) affected neither recruitment of macrophages to the region of injury nor their proliferation. In CsA-treated P6s (n = 28), reduction of the macrophage population and its proliferative activity was also seen but was much smaller than that following FK506 administration. Discussion: High effectiveness of FK506 in regulation of the inflammatory response and neuroprotection observed in the adult brain can also be considered as a possible indirect determinant of neuronal survival following the brain injury at very early developmental stages. pl
dc.description.volume 31 pl
dc.description.number 10 pl
dc.identifier.doi 10.1179/174313209X383295 pl
dc.identifier.eissn 1743-1328 pl
dc.title.journal Neurological Research pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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