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Aspirin resistance in adult patients after Fontan surgery

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Aspirin resistance in adult patients after Fontan surgery

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dc.contributor.author Tomkiewicz-Pająk, Lidia [SAP20013207] pl
dc.contributor.author Wójcik, Tomasz [SAP14005849] pl
dc.contributor.author Chłopicki, Stefan [SAP20000969] pl
dc.contributor.author Olszowska, Maria [SAP20000875] pl
dc.contributor.author Pająk, Jacek pl
dc.contributor.author Podolec, Jakub [SAP20002392] pl
dc.contributor.author Sitek, Barbara [SAP14005869] pl
dc.contributor.author Musiałek, Piotr [SAP20002648] pl
dc.contributor.author Rubiś, Paweł [SAP20012861] pl
dc.contributor.author Komar, Monika pl
dc.contributor.author Podolec, Piotr [SAP20000862] pl
dc.date.accessioned 2015-02-16T15:46:52Z
dc.date.available 2015-02-16T15:46:52Z
dc.date.issued 2015 pl
dc.identifier.issn 0167-5273 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/3117
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Aspirin resistance in adult patients after Fontan surgery pl
dc.type JournalArticle pl
dc.description.physical 19-26 pl
dc.abstract.en Background: Thrombotic complications are common in adult patients who have had a Fontan operation early in life for treatment of congenital heart disease. Objective: To characterize platelet function and responsiveness to aspirin in relation to thrombogenesis, systemic inflammation, and markers of endothelial function in adults with Fontan circulation (FC). Methods: Thirty-four FC patients (age 18–40 years; 62% taking aspirin chronically and 38% not taking aspirin) and 32 age- and sex-matched healthy controls were studied. Platelet function was evaluated by measurement of basal concentrations of thromboxane B2 (TXB2) and sCD40L and ex-vivo generation of TXB2 and sCD40L. Plasma concentrations of thrombin–antithrombin, endothelin-1, vWF, IL-6, IL-8, MCP-1, MIP-1β, TNFα, sVCAM-1, and syndecan-1 also were measured. Results: Platelet numbers were significantly lower in FC patients than in controls, but the patients had significantly higher platelet activity, as evidenced by higher TXB2 and sCD40L concentrations and higher ex vivo generation of TXB2. Chronic aspirin treatment had no effect on plasma concentrations of TXB2 and sCD40L in FC, but in 52% of aspirin-treated FC subjects, TXB2 concentrations remained elevated at 60 min of TXB2 generation, indicating aspirin resistance. In addition, FC patients had increased levels of thrombin–antithrombin, endothelin-1, vWF, IL-8, MCP-1, MIP-1β, TNFα, sVCAM-1, and syndecan-1 but not of IL-6. Conclusion: Adults with FC had lower platelet numbers but increased platelet activity, increased thrombogenesis, systemic inflammation, and endothelial dysfunction. A significant proportion of aspirin-treated FC adults had aspirin resistance, which may be at least in part responsible for their increased incidence of thrombotic complications. pl
dc.subject.en Fontan surgery pl
dc.subject.en Platelet reactivity pl
dc.subject.en Thromboxane B2 generation test pl
dc.subject.en inflammation pl
dc.subject.en endothelial function pl
dc.subject.en aspirin resistance pl
dc.description.volume 181 pl
dc.description.points 40 pl
dc.identifier.doi 10.1016/j.ijcard.2014.11.219 pl
dc.identifier.eissn 1874-1754 pl
dc.title.journal International Journal of Cardiology pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Instytut Kardiologii pl
dc.affiliation Pion Rektora : Jagiellońskie Centrum Rozwoju Leków pl
dc.affiliation Wydział Lekarski : Zakład Farmakologii Doświadczalnej pl
dc.subtype Article pl
dc.cm.id 69309
.pointsMNiSW [2015 A]: 35


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