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Bibliographic description

punktacja MEiN [2015 A]: 35 

title:	Aspirin resistance in adult patients after Fontan surgery
author:	Tomkiewicz-Pająk Lidia , Wójcik Tomasz , Chłopicki Stefan , Olszowska Maria , Pająk Jacek, Podolec Jakub , Sitek Barbara , Musiałek Piotr , Rubiś Paweł , Komar Monika, Podolec Piotr
journal title:	International Journal of Cardiology
volume:	181
date of publication :	2015
pages:	19-26
ISSN:	0167-5273
eISSN:	1874-1754
DOI:	10.1016/j.ijcard.2014.11.219
language:	English
journal language:	English
abstract in English:	Background: Thrombotic complications are common in adult patients who have had a Fontan operation early in life for treatment of congenital heart disease. Objective: To characterize platelet function and responsiveness to aspirin in relation to thrombogenesis, systemic inflammation, and markers of endothelial function in adults with Fontan circulation (FC). Methods: Thirty-four FC patients (age 18–40 years; 62% taking aspirin chronically and 38% not taking aspirin) and 32 age- and sex-matched healthy controls were studied. Platelet function was evaluated by measurement of basal concentrations of thromboxane B2 (TXB2) and sCD40L and ex-vivo generation of TXB2 and sCD40L. Plasma concentrations of thrombin–antithrombin, endothelin-1, vWF, IL-6, IL-8, MCP-1, MIP-1β, TNFα, sVCAM-1, and syndecan-1 also were measured. Results: Platelet numbers were significantly lower in FC patients than in controls, but the patients had significantly higher platelet activity, as evidenced by higher TXB2 and sCD40L concentrations and higher ex vivo generation of TXB2. Chronic aspirin treatment had no effect on plasma concentrations of TXB2 and sCD40L in FC, but in 52% of aspirin-treated FC subjects, TXB2 concentrations remained elevated at 60 min of TXB2 generation, indicating aspirin resistance. In addition, FC patients had increased levels of thrombin–antithrombin, endothelin-1, vWF, IL-8, MCP-1, MIP-1β, TNFα, sVCAM-1, and syndecan-1 but not of IL-6. Conclusion: Adults with FC had lower platelet numbers but increased platelet activity, increased thrombogenesis, systemic inflammation, and endothelial dysfunction. A significant proportion of aspirin-treated FC adults had aspirin resistance, which may be at least in part responsible for their increased incidence of thrombotic complications.
keywords in English:	Fontan surgery, Platelet reactivity, Thromboxane B2 generation test, inflammation, endothelial function, aspirin resistance
departmental parameterization:	40
affiliation:	Wydział Lekarski : Instytut Kardiologii, Pion Rektora : Jagiellońskie Centrum Rozwoju Leków, Wydział Lekarski : Zakład Farmakologii Doświadczalnej
type:	journal article
subtype:	academic paper

This item appears in the following Collection(s)

• ROD UJ
  
• Publikacje naukowe
  
• Publikacje Collegium Medicum