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Different effects of neuroprotectants FK-506 and cyclosporin A on susceptibility to pilocarpine-induced seizures in rats with brain injured at different developmental stages

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Different effects of neuroprotectants FK-506 and cyclosporin A on susceptibility to pilocarpine-induced seizures in rats with brain injured at different developmental stages

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dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.contributor.author Kaczyńska, Małgorzata [SAP12018418] pl
dc.contributor.author Guzik, Rafał pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-09-28T12:21:42Z
dc.date.available 2016-09-28T12:21:42Z
dc.date.issued 2004 pl
dc.identifier.issn 0920-1211 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30943
dc.language eng pl
dc.title Different effects of neuroprotectants FK-506 and cyclosporin A on susceptibility to pilocarpine-induced seizures in rats with brain injured at different developmental stages pl
dc.type JournalArticle pl
dc.description.physical 63-72 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz; Małgorzata Kaczyńska podpisana: Małgorzata Ciarach pl
dc.abstract.other Susceptibility of the injured brain to epileptic seizures depends on the developmental stage at which the injury had been inflicted (our previous paper published in Epilepsy Res. 53 (2003) 216-224). The present Study was designed to examine whether neuroprotective agents applied following the injury can decrease the seizure susceptibility. In order to solve this problem, the left cerebral hemisphere was mechanically injured in 6- and 30-day-old Wistar rats. Neuroprotectants FK506 or Cyclosporin A (CsA) were injected 20 min and 24 h following the injury. On postnatal day 60, all the animals received single i.p. pilocarpine injections to evoke epileptic seizures. During a 6 h period following the injection, the animals were observed continuously and pilocarpine-induced symptoms were recorded and rated. The animals were sacrificed 7 days after pilocarpine injection. In rats injured on postnatal days 6 or 30 (P6 or P30, respectively) and injected with FK-506 after the injury, signs of amelioration in the course of epilepsy were observed. Generally, proportions of rats suffering from heavy seizures were lower and/or their survival periods were longer. Following treatment with CsA, proportions of rats displaying heavy seizures were greater. It was accompanied by extremely high mortality (in rats injured on P6) or a longer duration of seizures (in rats injured on P30). The results appear to point to age-dependent differences between the mechanisms of action of the two neuroprotectants. pl
dc.description.volume 61 pl
dc.description.number 1-3 pl
dc.identifier.doi 10.1016/j.eplepsyres.2004.06.001 pl
dc.identifier.eissn 1872-6844 pl
dc.title.journal Epilepsy Research pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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