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Interleukin-1\beta affects the macrophage recruitment and proliferation in the injured brain of 6-day-old rat

Interleukin-1\beta affects the macrophage recruitment ...

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dc.contributor.author Pawliński, Rafał pl
dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.contributor.author Małodzińska, Katarzyna pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-09-28T11:28:08Z
dc.date.available 2016-09-28T11:28:08Z
dc.date.issued 1999 pl
dc.identifier.issn 0065-1400 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30931
dc.language eng pl
dc.title Interleukin-1\beta affects the macrophage recruitment and proliferation in the injured brain of 6-day-old rat pl
dc.type JournalArticle pl
dc.description.physical 271-278 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz pl
dc.identifier.weblink http://www.ane.pl/pdf/5923.pdf pl
dc.abstract.other Six-day-old male rats received a mechanical lesion in the left cerebral hemisphere. Thereafter, a single dose of either 5, 50 or 500 units (U) of recombinant rat interleukin-1 beta (IL-1 beta) was injected into the lesion cavity. One or 2 days after the injury, the rats were injected with H-3-thymidine. Brain sections were subjected to BSI-B4 lectin histochemistry and autoradiography to visualise proliferating and non-proliferating macrophages located within the region of injury. A mitogenic effect of IL-1 beta on macrophages was observed on day 2 in brains injected with the lowest 5 U dose of cytokine. Following administration of higher 50 U and 500 U doses, infiltration of the injured tissue by macrophages was significantly intensified on day 1. However, on day 2, dose-dependent reductions of the total number of macrophages as well as their proliferative activity were recorded. The findings suggest that the higher the initial quantity of macrophages,the sooner they disappeared from the injury site. It may therefore be hypothesised that IL-1 beta-induced increase in macrophage recruitment at the beginning of the inflammatory response speeded the removal of tissue debris and, therefore, accelerated healing of the injured nervous tissue. pl
dc.description.volume 59 pl
dc.description.number 4 pl
dc.identifier.eissn 1689-0035 pl
dc.title.journal Acta Neurobiologiae Experimentalis pl
dc.language.container eng pl
dc.date.accession 2016-09-28 pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl

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