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Synaptic plasticity, astrocytes and morphological homeostasis

Synaptic plasticity, astrocytes and morphological ...

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dc.contributor.author Ślęzak, Michał [USOS58579] pl
dc.contributor.author Pfrieger, Frank W. pl
dc.contributor.author Sołtys, Zbigniew [SAP11012054] pl
dc.date.accessioned 2016-09-28T10:47:48Z
dc.date.available 2016-09-28T10:47:48Z
dc.date.issued 2006 pl
dc.identifier.issn 0928-4257 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30922
dc.language eng pl
dc.title Synaptic plasticity, astrocytes and morphological homeostasis pl
dc.type JournalArticle pl
dc.description.physical 84-91 pl
dc.abstract.other Recent discoveries suggest that astrocytes are an integral part of synaptic connections, as they sense and modulate synaptic activity. Moreover, there is evidence that astrocytes change the number of synaptic connections directly via synaptogenic signals or indirectly, by modifying the morphology of axons and dendrites. Here, we formulate the hypothesis that astrocytes mediate the morphological homeostasis of nerve cells, which is any adaptation of the morphology of a neuron to preserve its ability to respond to and generate synaptic activity during learning and mernory-induced changes. We argue that astrocytes control neuronal morphology locally and across long-ranging assemblies of neurons and that on the other hand, astrocytes, are part of the engram with plasticity-related changes affecting their morphology. pl
dc.description.volume 99 pl
dc.description.number 2-3 pl
dc.identifier.doi 10.1016/j.jphysparis.2005.12.082 pl
dc.identifier.eissn 1769-7115 pl
dc.title.journal Journal of Physiology. Paris pl
dc.title.volume The World of the Synapse : Molecular Basis, Pathologies and Drug Discovery pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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