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Effects of intracerebral administration of IL-1beta on reactive behaviors of astrocytes and macrophages in the injured brain of newborn rats

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Effects of intracerebral administration of IL-1beta on reactive behaviors of astrocytes and macrophages in the injured brain of newborn rats

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dc.contributor.author Pawliński, Rafał pl
dc.contributor.author Sołtys, Zbigniew [SAP11012054] pl
dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.contributor.author Kubala, Edyta pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-09-28T10:40:00Z
dc.date.available 2016-09-28T10:40:00Z
dc.date.issued 2000 pl
dc.identifier.issn 0239-8508 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30919
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Effects of intracerebral administration of IL-1beta on reactive behaviors of astrocytes and macrophages in the injured brain of newborn rats pl
dc.type JournalArticle pl
dc.description.physical 151-156 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz pl
dc.abstract.other Newborn male rats were subjected to a mechanical lesion of the left cerebral hemisphere. Thereafter, a single dose 5 or 500 units (U) of recombinant rat interleukin-1 beta (IL-1 beta) was injected into the lesion cavity. One or 2 days after the injury, the rats were injected with H-3-thymidine to label dividing cells. Brain sections were subjected to GFAP immunocytochemistry or BSI-B4 lectin histochemistry to visualise astrocytes or macrophages, respectively. Autoradiography was used to detect cells proliferating within the region of injury in the immunocytochemically stained brain sections. The strongest mitogenic effect of IL-1 beta on astrocytes (labeling index) was observed on day 1 after injury while a dose-dependent increase in their GFAP-immunoreactivity occurred on day 2. At 500U dose, IL-1 beta significantly reduced infiltration of macrophages on posttraumatic days 1 and 2 but did not influence their proliferation. Thus, effects of IL-1 beta on the occurrence of macrophages were opposite to those on the GFAP-immunoreactivity of astrocytes and their proliferation. It appears to suggest existence of different mechanisms controlling reactive behaviors of the two cell populations. pl
dc.description.volume 38 pl
dc.description.number 4 pl
dc.identifier.eissn 1897-5631 pl
dc.title.journal Folia Histochemica et Cytobiologica pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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