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Effects of prenatal gamma-irradiation on postnatal astrogliogenesis in the hippocampal formation of rat

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Effects of prenatal gamma-irradiation on postnatal astrogliogenesis in the hippocampal formation of rat

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dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.contributor.author Frączek, Maria pl
dc.contributor.author Kochowska, Joanna pl
dc.date.accessioned 2016-09-28T10:29:29Z
dc.date.available 2016-09-28T10:29:29Z
dc.date.issued 1999 pl
dc.identifier.issn 0006-8993 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30914
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Effects of prenatal gamma-irradiation on postnatal astrogliogenesis in the hippocampal formation of rat pl
dc.type JournalArticle pl
dc.description.physical 628-632 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz pl
dc.abstract.other Female Wistar rats were exposed to a single 1.0 Cy dose of gamma radiation on gestational days 13, 15, 17 or 19 (E13, E15, E17 and E19, respectively). Their 8- and 16-day old male offsprings were injected with H-3-thymidine and sacrificed 4 h after the injection. Brain sections were immunostained for S100 beta protein and subjected to autoradiography. Thereafter, the dorsal parr of the hippocampal formation was examined microscopically and numbers and locations of proliferating astrocytes were recorded. Following prenatal irradiation, the intensity of astrocyte proliferation was considerably reduced, especially in the region of dentate gyrus. The reduction showed regular trend of changes being much stronger in brains irradiated on E19 than in those irradiated on E13. The changes, therefore, were related to the stage of brain development at which the irradiation was performed. A possible role of neuronal regulatory influence on the postnatal development of glial cells was discussed. pl
dc.description.volume 816 pl
dc.description.number 2 pl
dc.identifier.doi 10.1016/S0006-8993(98)01247-5 pl
dc.identifier.eissn 1872-6240 pl
dc.title.journal Brain Research pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Report pl
dc.rights.original bez licencji pl


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