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An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain

An inhibitory effect of interferon gamma on the ...

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dc.contributor.author Pawliński, Rafał pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-09-28T09:50:25Z
dc.date.available 2016-09-28T09:50:25Z
dc.date.issued 1997 pl
dc.identifier.issn 0006-8993 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30905
dc.language eng pl
dc.title An inhibitory effect of interferon gamma on the injury-induced astrocyte proliferation in the postmitotic rat brain pl
dc.type JournalArticle pl
dc.description.physical 231-234 pl
dc.abstract.other Influence of interferon gamma (IFN gamma) on astrocytes proliferating in response to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats. The brain injury was followed by an immediate injection of IFN gamma into the lesion cavity. On 1st or 2nd day following injury the animals were injected with [H-3]thymidine and killed 4 h after the injection. The proliferating astrocytes were visualised by combination of immunocytochemical staining for glial fibrillary acidic protein (GFAP) and autoradiography. Thereafter, numbers of GFAP-immunopositive and autoradiographically-labeled astrocytes located within the region of injury were counted. On the day 1 after injury no effect of lFN gamma administration was seen. However, on day 2 the average 43% reduction of the number of proliferating astrocytes was recorded. The reduction showed no dose-dependent changes. This in vivo evidence of IFN gamma-induced suppression of astrocyte proliferation was considered in relation to other determinants of astrocyte reactivity existing in the injured brain. pl
dc.description.volume 773 pl
dc.description.number 1-2 pl
dc.identifier.doi 10.1016/S0006-8993(97)01024-X pl
dc.identifier.eissn 1872-6240 pl
dc.title.journal Brain Research pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype OtherDocuments pl
dc.rights.original bez licencji pl


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