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Spatiotemporal patterns of microglial proliferation in rat brain injured at the postmitotic stage of postnatal development

Spatiotemporal patterns of microglial proliferation ...

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dc.contributor.author Ziaja, Marek [SAP11015503] pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-09-28T09:08:51Z
dc.date.available 2016-09-28T09:08:51Z
dc.date.issued 1999 pl
dc.identifier.issn 0360-4012 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30892
dc.language eng pl
dc.title Spatiotemporal patterns of microglial proliferation in rat brain injured at the postmitotic stage of postnatal development pl
dc.type JournalArticle pl
dc.description.physical 379-386 pl
dc.abstract.other Changes in the number and distribution of microglial cells proliferating in response to unilateral injury of the cerebral hemisphere were investigated in 30-day-old rats. Twelve hours or 1, 2, 4, or 8 days following the injury the rats were injected with H-3-thymidine and killed 4 hr later. Brain sections were processed for BSI-B4 isolectin histochemistry followed by autoradiography, During microscopic observations, four morphological types of lectin-positive and autoradiographically labeled cells were distinguished: 1) ramified, 2) hypertrophic, 3) bushy, and 4) macrophages, Subsequently, numbers and locations of the cell types within the injury area were recorded at different stages of the experiment. The earliest signs of the proliferative response were displayed 12 hr after injury by ramified microglia, On the first day after injury, those cells represented about 50% of the whole cell population and were spread at relatively the longest distances from the lesion site, During subsequent stages of the response, a considerable reduction of the area occupied by proliferating microglia corresponded with a dramatic quantitative decrease of their ramified fraction and a simultaneous increase of their more advanced reactive forms and macrophages. pl
dc.description.volume 58 pl
dc.description.number 3 pl
dc.identifier.doi 10.1002/(SICI)1097-4547(19991101)58:3<379::AID-JNR3>3.0.CO;2-J pl
dc.identifier.eissn 1097-4547 pl
dc.title.journal Journal of Neuroscience Research pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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