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Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue

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Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue

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dc.contributor.author Chwiej, Joanna pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.contributor.author Marciszko, Marianna pl
dc.contributor.author Czyżycki, Mateusz pl
dc.contributor.author Rickers, Karen pl
dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.date.accessioned 2016-09-27T13:32:12Z
dc.date.available 2016-09-27T13:32:12Z
dc.date.issued 2010 pl
dc.identifier.issn 0949-8257 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30852
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue pl
dc.type JournalArticle pl
dc.description.physical 283-289 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz pl
dc.abstract.other In the present work, X-ray fluorescence microscopy with a synchrotron Source for the exciting radiation was applied for topographic and quantitative elemental analysis of rat brain tissue in pilocarpine-induced epilepsy and neuroprotection with FK-506. The mass per unit area of the elements P, S, Cl, K, Ca, Fe, Cu, Zn, Se, Br, and Rb was determined in four fields of the hippocampal formation (sectors I and 3 of Ammon's horn-CA1, CA3; dentate gyrus; hilus of dentate gyrus) and the parietal cortex. The results obtained for epileptic rats treated with FK-506 (SNF) were compared with data obtained previously for epileptic rats (SNS) and a control group. Many statistically significant differences in elemental composition were observed between the SNF and SNS groups. Higher mass per unit area of P was noticed in CA1 and CA3 regions of the hippocampus of SNF rats in comparison with SNS rats. A similar relation was observed for K in all five brain areas analyzed. Also, Fe in CA3 and dentate gyrus, CU in the parietal cortex, and Zn in CA3 and in the cortex were present at a higher level in the SNF group in comparison with the SNS group. The findings obtained in the present study suggest that the neuroprotective action of FK-506 in epileptic rat brain may involve not only the inhibition of calcineurin but also blockade of the K(+) channels. pl
dc.description.volume 15 pl
dc.description.number 2 pl
dc.identifier.doi 10.1007/s00775-009-0597-2 pl
dc.identifier.eissn 1432-1327 pl
dc.title.journal JBIC. Journal of Biological Inorganic Chemistry pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2010 A]: 32


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