Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue

doi:10.1007/s00775-009-0597-2

Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue

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Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue

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punktacja MEiN [2010 A]: 32

title:	Neuroprotective action of FK-506 (tacrolimus) after seizures induced with pilocarpine : quantitative and topographic elemental analysis of brain tissue
author:	Chwiej Joanna, Janeczko Krzysztof , Marciszko Marianna, Czyżycki Mateusz, Rickers Karen, Setkowicz-Janeczko Zuzanna
journal title:	JBIC. Journal of Biological Inorganic Chemistry
volume:	15
issue:	2
date of publication :	2010
pages:	283-289
ISSN:	0949-8257
eISSN:	1432-1327
DOI:	10.1007/s00775-009-0597-2
notes:	Zuzanna Setkowicz-Janeczko podpisana: Zuzanna Setkowicz
language:	English
journal language:	English
abstract in other languages:	In the present work, X-ray fluorescence microscopy with a synchrotron Source for the exciting radiation was applied for topographic and quantitative elemental analysis of rat brain tissue in pilocarpine-induced epilepsy and neuroprotection with FK-506. The mass per unit area of the elements P, S, Cl, K, Ca, Fe, Cu, Zn, Se, Br, and Rb was determined in four fields of the hippocampal formation (sectors I and 3 of Ammon's horn-CA1, CA3; dentate gyrus; hilus of dentate gyrus) and the parietal cortex. The results obtained for epileptic rats treated with FK-506 (SNF) were compared with data obtained previously for epileptic rats (SNS) and a control group. Many statistically significant differences in elemental composition were observed between the SNF and SNS groups. Higher mass per unit area of P was noticed in CA1 and CA3 regions of the hippocampus of SNF rats in comparison with SNS rats. A similar relation was observed for K in all five brain areas analyzed. Also, Fe in CA3 and dentate gyrus, CU in the parietal cortex, and Zn in CA3 and in the cortex were present at a higher level in the SNF group in comparison with the SNS group. The findings obtained in the present study suggest that the neuroprotective action of FK-506 in epileptic rat brain may involve not only the inhibition of calcineurin but also blockade of the K(+) channels.
affiliation:	Wydział Biologii i Nauk o Ziemi : Instytut Zoologii
type:	journal article
subtype:	academic paper

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