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Spatio-temporal pattern of proliferation of immunoglobulin G-containing astrocytes in the injured mouse cerebral hemisphere

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Spatio-temporal pattern of proliferation of immunoglobulin G-containing astrocytes in the injured mouse cerebral hemisphere

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dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.date.accessioned 2016-09-27T13:19:08Z
dc.date.available 2016-09-27T13:19:08Z
dc.date.issued 1995 pl
dc.identifier.issn 0239-8508 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30848
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Spatio-temporal pattern of proliferation of immunoglobulin G-containing astrocytes in the injured mouse cerebral hemisphere pl
dc.type JournalArticle pl
dc.description.physical 143-149 pl
dc.abstract.other Following a mechanical injury of the cerebral hemisphere in adult mice, [H-3]thymidine was injected at different time intervals to reveal proliferating cells. Brain section were double for immunoglobulin G (IgG) and glial fibrillary acidic protein (GFAP), and subjected to autoradiography. The procedure allowed to distinguish four cell types: (1) proliferating process-bearing cells immunopositive for IgG but expressing no GFAP (GFAP-/IgG+PB cells) (2) proliferating and (3) non-proliferating astrocytes immunopositive both for GFAP and IgG (GFAP+/IgG+), (4) proliferating astrocytes expressing GFAP and containing no IgG (GFAP+/IgG-). Thereafter, the distribution of each cell type within the injury area was recorded at each stage of the experiment and displayed as contour line maps. During the whole posttraumatic period, areas of very strong proliferation of GFAP-/IgG+PB-cells were located within deep layers of the cerebral cortex and in the white matter around the bottom part of the lesion. Few proliferating GFAP+/IgG+ astrocytes were mainly located in the same regions. However, changes in the distribution of proliferating astrocytes containing no IgG followed different spatio-temporal pattern. On the 4th day after injury areas of their proliferative activity surrounded both the bottom and superficial parts of the lesion. It seems that the immediate contact with the extravasated blood serum does not determine IgG cellular uptake. The uptake appears to depend on the cell type and its role in re-establishing the extracellular space in the injured brain tissue. pl
dc.description.volume 33 pl
dc.description.number 3 pl
dc.identifier.eissn 1897-5631 pl
dc.title.journal Folia Histochemica et Cytobiologica pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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