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Changes in the nitric oxide level in the rat liver as a response to brain injury

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Changes in the nitric oxide level in the rat liver as a response to brain injury

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dc.contributor.author Ziaja, Marek [SAP11015503] pl
dc.contributor.author Pyka, Janusz [SAP11117259] pl
dc.contributor.author Boczkuś, Bożena pl
dc.contributor.author Płonka, Beata [SAP11016806] pl
dc.contributor.author Płonka, Przemysław [SAP11015581] pl
dc.date.accessioned 2016-09-26T12:36:38Z
dc.date.available 2016-09-26T12:36:38Z
dc.date.issued 2011 pl
dc.identifier.issn 1089-8603 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30767
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Changes in the nitric oxide level in the rat liver as a response to brain injury pl
dc.type JournalArticle pl
dc.description.physical 423-430 pl
dc.abstract.other Liver disturbances stimulate inflammatory reaction in the brain but little is known if injury to the brain can significantly influence liver metabolism. This problem is crucial in modern transplantology, as the condition of the donor brain seems to strongly affect the quality (viability) of the graft, which is often obtained from brain-dead donors, usually after traumatic brain injury. Because nitric oxide is one of the significant molecules in brain and liver biology, we examined if brain injury can affect NO level in the liver. Liver samples of Wistar rats were collected and studied with EPR NO-metry to detect NO level changes at different time points after brain injury. Shortly after the trauma, NO level in the liver was similar to the control. However, later there was a significant increase in the NO content in the livers starting from the 2nd day after brain injury and lasting up to the 7th day. It seems that the response to a mechanical brain injury is of the systemic, rather than local character. Therefore brain metabolism disturbances can influence liver metabolism at least by stimulating the organ to produce NO. pl
dc.description.volume 25 pl
dc.description.number 4 pl
dc.identifier.doi 10.1016/j.niox.2011.07.004 pl
dc.identifier.eissn 1089-8611 pl
dc.title.journal Nitric Oxide pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki Molekularnej pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2011 A]: 25


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