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X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury

X-ray fluorescence analysis of long-term changes in ...

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dc.contributor.author Chwiej, Joanna pl
dc.contributor.author Sarapata, Adrian pl
dc.contributor.author Janeczko, Krzysztof [SAP11008688] pl
dc.contributor.author Stęgowski, Zdzisław pl
dc.contributor.author Appel, Karen pl
dc.contributor.author Setkowicz-Janeczko, Zuzanna [SAP11017135] pl
dc.date.accessioned 2016-09-23T08:41:14Z
dc.date.available 2016-09-23T08:41:14Z
dc.date.issued 2011 pl
dc.identifier.issn 0949-8257 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/30653
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/pl/legalcode *
dc.title X-ray fluorescence analysis of long-term changes in the levels and distributions of trace elements in the rat brain following mechanical injury pl
dc.type JournalArticle pl
dc.description.physical 275-283 pl
dc.description.additional Zuzanna Setkowicz-Janeczko podpisana nazwiskiem Setkowicz pl
dc.abstract.en This paper describes the results of the application of X-ray fluorescence microscopy to the qualitative, topographic and quantitative elemental analysis of nervous tissue from rats with neocortical brain injury. The tissue samples were analyzed with a 15 mu m beam defined by the size of the polycapillary focus. Raster scanning of the samples generated 2D cartographies, revealing the distributions of elements such as P, S, Cl, K, Ca, Fe, Cu, and Zn. Special emphasis was placed on the analysis of the areas neighboring the lesion site and the hippocampal formation tissue. The results obtained for rats with mechanical brain injuries were compared with those recorded for controls and animals with pilocarpine-induced seizures. There were no significant differences in the elemental compositions of gray and white matter between injured and uninjured brain hemispheres. A higher level of Ca was observed in the gray matter of both of the hemispheres in brains with neocortical injuries. A similar relation was noticed for Fe in the white matter. A comparative study of hippocampal formation tissue showed a statistically significant decrease in the mass per unit area of P in the dentate gyrus (DG) and the hilus (H) of DG for animals with brain lesions in comparison with the control group. Analogous relations were found for Cu in the DG and Zn in sector 3 of Ammon's horn (CA3) and the DG. It is important to note that identical changes in the same areas were observed for animals with pilocarpine-induced seizures in our previous study. pl
dc.description.volume 16 pl
dc.description.number 2 pl
dc.identifier.doi 10.1007/s00775-010-0724-0 pl
dc.identifier.eissn 1432-1327 pl
dc.title.journal JBIC. Journal of Biological Inorganic Chemistry pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original CC-BY-NC; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2011 A]: 35


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa