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Kininogen adsorption to the cell surface of Candida spp.

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Kininogen adsorption to the cell surface of Candida spp.

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dc.contributor.author Rąpała-Kozik, Maria [SAP11012697] pl
dc.contributor.author Karkowska-Kuleta, Justyna [SAP13036970] pl
dc.contributor.author Jacher, Agnieszka pl
dc.contributor.author Gołda, Anna pl
dc.contributor.author Barbasz, Anna [USOS13109] pl
dc.contributor.author Guevara Lora, Ibeth [SAP11017332] pl
dc.contributor.author Kozik, Andrzej [SAP11010989] pl
dc.date.accessioned 2015-02-13T06:46:30Z
dc.date.available 2015-02-13T06:46:30Z
dc.date.issued 2008 pl
dc.identifier.issn 1567-5769 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/3063
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Kininogen adsorption to the cell surface of Candida spp. pl
dc.type JournalArticle pl
dc.description.physical 237-241 pl
dc.abstract.en The invasion of human host by pathogenic microorganisms is often associated with increased kinin production which may occur due to the action of pathogen secretory proteinases or the activation of host's surface-dependent kinin generation cascade, initiated by the adsorption of high molecular weight kininogen (HK) on the pathogen cells. In this work we characterize for the first time the binding of HK by Candida yeasts and analyze this adsorption in terms of intraspecific variation and a dependence on the fungal morphology. The apparent dissociation constants for this interaction were in the order of 10− 7 M and the binding capacity increased in the order: Candida glabrata < Candida parapsilosis < Candida krusei < Candida albicans < Candida tropicalis, in a good correlation with the general fungus pathogenicity. Within one species, the more invasive filamentous forms bound HK stronger than the yeast forms. The binding activity was assigned to a fraction of cell surface mannoproteins which were extracted from yeast cell walls by β-1,3-glucanase and mercaptoethanol treatment. pl
dc.subject.en kinins pl
dc.subject.en high molecular weight kininogen pl
dc.subject.en host–pathogen interaction pl
dc.subject.en Candida spp pl
dc.subject.en yeast-hyphal growth pl
dc.subject.en yeast cell wall mannoproteins pl
dc.description.volume 8 pl
dc.description.number 2 pl
dc.identifier.doi 10.1016/j.intimp.2007.07.005 pl
dc.identifier.eissn 1878-1705 pl
dc.title.journal International Immunopharmacology pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biochemii Analitycznej pl
dc.subtype Article pl


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