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Fungi pathogenic to humans : molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus

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Fungi pathogenic to humans : molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus

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dc.contributor.author Karkowska-Kuleta, Justyna [SAP13036970] pl
dc.contributor.author Rąpała-Kozik, Maria [SAP11012697] pl
dc.contributor.author Kozik, Andrzej [SAP11010989] pl
dc.date.accessioned 2015-02-12T10:58:29Z
dc.date.available 2015-02-12T10:58:29Z
dc.date.issued 2009 pl
dc.identifier.issn 0001-527X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/3048
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-sa/4.0/pl/legalcode *
dc.title Fungi pathogenic to humans : molecular bases of virulence of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus pl
dc.type JournalArticle pl
dc.description.physical 211-224 pl
dc.identifier.weblink https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2452/1069 pl
dc.abstract.en The frequency of severe systemic fungal diseases has increased in the last few decades. The clinical use of antibacterial drugs, immunosuppressive agents after organ transplantation, cancer chemotherapy, and advances in surgery are associated with increasing risk of fungal infections. Opportunistic pathogens from the genera Candida and Aspergillus as well as pathogenic fungi from the genus Cryptococcus can invade human organism and may lead to mucosal and skin infections or to deep-seated mycoses of almost all inner organs, especially in immunocompromised patients. Nowadays, there are some effective antifungal agents, but, unfortunately, some of the pathogenic species show increasing resistance. The identification of fungal virulence factors and recognition of mechanisms of pathogenesis may lead to development of new efficient antifungal therapies. This review is focused on major virulence factors of the most common fungal pathogens of humans: Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. The adherence to host cells and tissues, secretion of hydrolytic enzymes, phenotypic switching and morphological dimorphism contribute to C. albicans virulence. The ability to grow at 37°C, capsule synthesis and melanin formation are important virulence factors of C. neoformans. The putative virulence factors of A. fumigatus include production of pigments, adhesion molecules present on the cell surface and secretion of hydrolytic enzymes and toxins.
dc.subject.en pathogenic fungi pl
dc.subject.en aspergillosis pl
dc.subject.en virulence factors pl
dc.subject.en candidiasis pl
dc.subject.en cryptococcosis pl
dc.description.volume 56 pl
dc.description.number 2 pl
dc.identifier.eissn 1734-154X pl
dc.title.journal Acta Biochimica Polonica pl
dc.language.container eng pl
dc.date.accession 2019-02-14 pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biochemii Analitycznej pl
dc.subtype Article pl
dc.rights.original CC-BY-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / P pl


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Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa