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New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary

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New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary

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dc.contributor.author Schmauck-Medina, Tomas pl
dc.contributor.author Moliere, Adrian pl
dc.contributor.author Lautrup, Sofie pl
dc.contributor.author Zhang, Jianying pl
dc.contributor.author Chłopicki, Stefan [SAP14004240] pl
dc.contributor.author Madsen, Helena Borland pl
dc.contributor.author Cao, Shuqin pl
dc.contributor.author Soendenbroe, Casper pl
dc.contributor.author Mansell, Els pl
dc.contributor.author Vestergaard, Mark Bitsch pl
dc.contributor.author Li, Zhiquan pl
dc.contributor.author Shiloh, Yosef pl
dc.contributor.author Opresko, Patricia L. pl
dc.contributor.author Egly, Jean-Marc pl
dc.contributor.author Kirkwood, Thomas pl
dc.contributor.author Verdin, Eric pl
dc.contributor.author Bohr, Vilhelm A. pl
dc.contributor.author Cox, Lynne S. pl
dc.contributor.author Stevnsner, Tinna pl
dc.contributor.author Rasmussen, Lene Juel pl
dc.contributor.author Fang, Evandro F. pl
dc.date.accessioned 2022-11-03T10:51:10Z
dc.date.available 2022-11-03T10:51:10Z
dc.date.issued 2022 pl
dc.identifier.issn 1945-4589 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/303202
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 3.0 *
dc.rights.uri http://creativecommons.org/licenses/by/3.0/legalcode *
dc.title New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary pl
dc.type JournalArticle pl
dc.description.physical 6829-6839 pl
dc.identifier.weblink https://www.aging-us.com/article/204248/text pl
dc.abstract.en Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the "old" and "new" hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly. pl
dc.description.volume 14 pl
dc.description.number 16 pl
dc.identifier.doi 10.18632/aging.204248 pl
dc.identifier.eissn 1945-4589 pl
dc.title.journal Aging-US pl
dc.language.container eng pl
dc.date.accession 2022-10-18 pl
dc.affiliation Pion Prorektora ds. badań naukowych : Jagiellońskie Centrum Rozwoju Leków pl
dc.subtype ReviewArticle pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; 2022-08-28 pl
dc.pbn.affiliation Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne pl
dc.cm.id 109834 pl
dc.cm.idOmega UJCM9e1b1fe446114221b13f17807687294b pl
.pointsMNiSW [2022 A]: 140


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Udzielam licencji. Uznanie autorstwa 3.0 Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 3.0