Repozytorium Uniwersytetu Jagiellońskiego

On how the motor cortices resolve an inter-hemispheric response conflict : an event-related EEG potential-guided TMS study of the flankers task

On how the motor cortices resolve an inter-hemispheric ...

Metadane (Dublin Core) Verleger, Rolf pl Kuniecki, Michał [SAP11018119] pl Möller, Frederike pl Fritzmannova, Michaela pl Siebner, Hartwig Roman Oman pl 2016-09-16T08:33:39Z 2016-09-16T08:33:39Z 2009 pl
dc.identifier.issn 0953-816X pl
dc.language eng pl
dc.title On how the motor cortices resolve an inter-hemispheric response conflict : an event-related EEG potential-guided TMS study of the flankers task pl
dc.type JournalArticle pl
dc.description.physical 318-326 pl
dc.identifier.weblink pl
dc.abstract.en An important aspect of human motor control is the ability to resolve conflicting response tendencies. Here we used single-pulse transcranial magnetic stimulation (TMS) to track the time course of excitability changes in the primary motor hand areas (M1HAND) while the motor system resolved response conflicts. Healthy volunteers had to respond fast with their right and left index fingers to right- and left-pointing arrows. These central target stimuli were preceded by flanking arrows, inducing premature response tendencies which competed with correct response activation. The time point of maximum premature activation was individually measured as peak latency of the lateralized readiness potential (LRP) in the EEG. In the subsequent TMS experiment, single pulses were applied to left or right M1HAND during the same flanker task. The amplitude of the motor evoked potentials in the contralateral first dorsal interosseus muscle was taken as an index of corticospinal excitability. Guided by the previous LRP measurement, magnetic stimuli were applied 0-90 ms after the individual LRP peak, to cover the epoch of conflict resolution. When flankers were incompatible with the target, excitability of the prematurely activated M1HAND gradually decreased during this 90 ms period. This decrease was paralleled by a mirror-symmetrical increase in excitability in the other M1HAND. These results show that the inappropriate response tendency is cancelled in one M1HAND simultaneously with activation of the correct response in the other. This integrated implementation of response activation and cancellation at the level of the M1HAND presumably represents a downstream effect orchestrated by premotor brain regions. pl
dc.subject.en lateralized readiness potential pl
dc.subject.en motor contro pl
dc.subject.en motor-evoked potentia pl
dc.subject.en transcranial magnetic stimulation pl
dc.description.volume 30 pl
dc.description.number 2 pl
dc.identifier.doi 10.1111/j.1460-9568.2009.06817.x pl
dc.identifier.eissn 1460-9568 pl
dc.title.journal European Journal of Neuroscience pl
dc.language.container eng pl
dc.affiliation Wydział Filozoficzny : Instytut Psychologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl

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