Novel method for screening of enteric film coatings properties with magnetic resonance imaging

Bibliographic description

punktacja MEiN [2013 A]: 35

title:	Novel method for screening of enteric film coatings properties with magnetic resonance imaging
author:	Dorożyński Przemysław , Jamróz Witold , Niwiński Krzysztof , Kurek Mateusz , Węglarz Władysław, Jachowicz Renata , Kulinowski Piotr
journal title:	International Journal of Pharmaceutics
volume:	456
issue:	2
date of publication :	2013
pages:	569-571
ISSN:	0378-5173
eISSN:	1873-3476
DOI:	10.1016/j.ijpharm.2013.08.004
language:	English
journal language:	English
abstract in English:	The aim of the study is to present the concept of novel method for fast screening of enteric coating compositions properties without the need of preparation of tablets batches for fluid bed coating. Proposed method involves evaluation of enteric coated model tablets in specially designed testing cell with application of MRI technique. The results obtained in the testing cell were compared with results of dissolution studies of mini-tablets coated in fluid bed apparatus. The method could be useful in early stage of formulation development for screening of film coating properties that will shorten and simplify the development works.
keywords in English:	shellac, mini-tablets, enteric coating, delayed release, magnetic resonance imaging, ultra-short echo time imaging, MRI, UTE
affiliation:	Wydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacji
type:	journal article
subtype:	academic paper