Cardiovascular anomalies among 1005 fetuses referred to invasive prenatal testing - a comprehensive cohort study of associated chromosomal aberrations

doi:10.3390/ijerph191610019

Cardiovascular anomalies among 1005 fetuses referred to invasive prenatal testing - a comprehensive cohort study of associated chromosomal aberrations

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Cardiovascular anomalies among 1005 fetuses referred to invasive prenatal testing - a comprehensive cohort study of associated chromosomal aberrations

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punktacja MEiN [2022]: 20

title:	Cardiovascular anomalies among 1005 fetuses referred to invasive prenatal testing - a comprehensive cohort study of associated chromosomal aberrations
author:	Wójtowicz Anna , Madetko-Talowska Anna , Wójtowicz Wojciech , Szewczyk Katarzyna , Huras Hubert , Bik-Multanowski Mirosław
journal title:	International Journal of Environmental Research and Public Health
volume:	19
issue:	16
date of publication :	2022
article ID:	10019
ISSN:	1661-7827
eISSN:	1660-4601
DOI:	10.3390/ijerph191610019
URL:	https://www.mdpi.com/1660-4601/19/16/10019
date accessed:	2022-08-31
language:	English
journal language:	English
abstract in English:	This retrospective cohort study comprehensively evaluates cardiovascular anomalies (CVAs) and associated extracardiac structural malformations (ECMs) among 1005 fetuses undergoing invasive prenatal testing at a single tertiary Polish center in the context of chromosomal aberrations detected in them by array comparative genomic hybridization (aCGH) and G-band karyotyping. The results of our study show that CVAs are among the most common malformations detected in fetuses undergoing invasive prenatal testing, as they affected 20% of all cases seen in our department. Septal defects predominated among fetuses with numerical aberrations, while conotruncal defects were the most common findings among fetuses with pathogenic copy number variants (CNVs). In 61% of cases, CVAs were associated with ECMs (the diagnosis was confirmed postnatally or in cases of pregnancy termination by means of autopsy). The most common ECMs were anomalies of the face and neck, followed by skeletal defects. In total, pathogenic chromosomal aberrations were found in 47.5% of CVAs cases, including 38.6% with numerical chromosomal aberrations. Pathogenic CNVs accounted for 14.5% of cases with CVAs and normal karyotype. Thus, our study highlights the importance of assessing the anatomy of the fetus, and of the genetic testing (preferably aCGH) that should be offered in all CVA and ECM cases.
keywords in English:	congenital heart defect, vascular anomaly, array comparative genomic hybridization, copy number variants, prenatal diagnosis, ultrasound
affiliation:	Wydział Lekarski : Instytut Pediatrii, Wydział Lekarski : Klinika Położnictwa i Perinatologii, Wydział Zarządzania i Komunikacji Społecznej : Katedra Systemów Informatycznych
type:	journal article
subtype:	academic paper