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Determination of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods

Determination of lipophilicity of α-(4-phenylpiperazine) ...

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dc.contributor.author Bajda, Marek [SAP20011142] pl
dc.contributor.author Bucki, Adam [SAP20012664] pl
dc.contributor.author Szlęk, Jakub [SAP20002579] pl
dc.contributor.author Szwaczkiewicz, Marta pl
dc.contributor.author Świerczek, Maciej pl
dc.contributor.author Malawska, Barbara [SAP20000689] pl
dc.date.accessioned 2015-02-10T09:11:16Z
dc.date.available 2015-02-10T09:11:16Z
dc.date.issued 2008 pl
dc.identifier.issn 0269-3879 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2947
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Determination of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods pl
dc.type JournalArticle pl
dc.description.physical 428-432 pl
dc.abstract.en This paper describes the evaluation of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides. We employed reversed-phase thin-layer chromatography (RP-TLC) and reversed-phase high performance liquid chromatography (RP-HPLC) as experimental methods, using mixtures of acetonitrile and water as the mobile phases with addition of 0.1%TFA in the HPLC experiments. Retention parameters (RM) and capacity factors (log k) determined by applying these methods were linearly dependent on the acetonitrile concentration and enabled us to estimate the relative lipophilicity factors: RM0 and log k0. These factors were compared with the calculated partition coefficients C log P obtained using several software packages. The results indicate that both experimental methods (RP-TLC and RP-HPLC) yielded similar results, and these methods enable determining the lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides. Significant correlations were found between log P values calculated by Pallas, ALOGPS and C log P Chem3D programs and the experimental data. pl
dc.subject.en lipophilicity pl
dc.subject.en RP-TLC and HPLC pl
dc.subject.en retention parameters RM0 pl
dc.subject.en log k0 capacity factors pl
dc.subject.en calculated partition coefficient pl
dc.subject.en N-benzylamides pl
dc.subject.en derivatives of 4-phenylpiperazine pl
dc.description.number 4 pl
dc.identifier.doi 10.1002/bmc.951 pl
dc.identifier.eissn 1099-0801 pl
dc.title.journal Biomedical Chromatography pl
dc.title.volume 22 pl
dc.language.container eng pl
dc.affiliation Wydział Farmaceutyczny : Zakład Fizykochemicznej Analizy Leku pl
dc.affiliation Wydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacji pl
dc.affiliation Wydział Farmaceutyczny : Zakład Chemii Leków pl
dc.subtype Article pl


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