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Determination of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods
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Determination of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods
Bibliographic description
| title: | Determination of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods |
| author: | Bajda Marek  , Bucki Adam , Szlęk Jakub , Szwaczkiewicz Marta, Świerczek Maciej, Malawska Barbara
|
| journal title: | Biomedical Chromatography |
| title of volume: | 22 |
| issue: | 4 |
| date of publication : | 2008 |
| pages: | 428-432 |
| ISSN: |
0269-3879 |
| eISSN: |
1099-0801 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | This paper describes the evaluation of lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides. We employed reversed-phase thin-layer chromatography (RP-TLC) and reversed-phase high performance liquid chromatography (RP-HPLC) as experimental methods, using mixtures of acetonitrile and water as the mobile phases with addition of 0.1%TFA in the HPLC experiments. Retention parameters (RM) and capacity factors (log k) determined by applying these methods were linearly dependent on the acetonitrile concentration and enabled us to estimate the relative lipophilicity factors: RM0 and log k0. These factors were compared with the calculated partition coefficients C log P obtained using several software packages. The results indicate that both experimental methods (RP-TLC and RP-HPLC) yielded similar results, and these methods enable determining the lipophilicity of α-(4-phenylpiperazine) derivatives of N-benzylamides. Significant correlations were found between log P values calculated by Pallas, ALOGPS and C log P Chem3D programs and the experimental data. |
| keywords in English: | lipophilicity, RP-TLC and HPLC, retention parameters RM0, log k0 capacity factors, calculated partition coefficient, N-benzylamides, derivatives of 4-phenylpiperazine |
| affiliation: | Wydział Farmaceutyczny : Zakład Fizykochemicznej Analizy Leku, Wydział Farmaceutyczny : Zakład Technologii Postaci Leku i Biofarmacji, Wydział Farmaceutyczny : Zakład Chemii Leków |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
