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Steroid levels and the spatiotemporal expression of steroidogenic enzymes and androgen receptor in developing ovaries of immature rats

Steroid levels and the spatiotemporal expression of ...

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dc.contributor.author Galas, Jerzy [SAP11006744] pl
dc.contributor.author Słomczyńska, Maria [SAP11008586] pl
dc.contributor.author Knapczyk-Stwora, Katarzyna [SAP11020105] pl
dc.contributor.author Grzesiak, Małgorzata [SAP13905673] pl
dc.contributor.author Starowicz, Agnieszka [USOS110303] pl
dc.contributor.author Tabarowski, Zbigniew [SAP11011896] pl
dc.contributor.author Rutka, Katarzyna pl
dc.contributor.author Szołtys, Maria [SAP11005057] pl
dc.date.accessioned 2016-07-09T12:41:03Z
dc.date.available 2016-07-09T12:41:03Z
dc.date.issued 2012 pl
dc.identifier.issn 0065-1281 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/28913
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Steroid levels and the spatiotemporal expression of steroidogenic enzymes and androgen receptor in developing ovaries of immature rats pl
dc.type JournalArticle pl
dc.description.physical 207-216 pl
dc.description.additional Małgorzata Grzesiak podpisana jako Małgorzata Durlej pl
dc.identifier.weblink http://www.sciencedirect.com/science/article/pii/S0065128111000742 pl
dc.abstract.en Immunoexpression of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), cytochrome P450c17 (P450c17), androgen receptor (AR), and steroid contents were studied in the ovaries of immature female Wistar rats killed between postnatal days 1 and 30. During days 1-7, ovarian somatic structures lacked AR, 3 beta-HSD and P450c17, except for the surface epithelium, which featured the presence of these three proteins, suggestive of its androgen responsiveness and steroidogenic function. On day 10, AR appeared in many somatic structures, including the granulosa layers, which coincided with the P450c17 immunoexpression in some theca/interstitial cells, and an increase in ovarian androgen concentration. On the following days a further rise in ovarian androgen and progesterone contents paralleled an increase in 3 beta-HSD and P450c17 immunoexpression in the theca layer cells and primary interstitial cells. However, the development of the follicles constituting the first follicular wave was aberrant, since they lacked AR expression until the preantral stage and were characterized by a delayed onset and much lower expression of the thecal P450c17. They could not ovulate, since ovarian content of estradiol was too low to evoke the LH surge. The clusters of the secondary interstitial cells found on day 30 exhibited predominant expression of 3 beta-HSD over P450c17, suggesting more intensive progesterone than androgen synthesis in these structures. pl
dc.subject.en rat pl
dc.subject.en steroidogenic enzymes pl
dc.subject.en ovarian development pl
dc.description.volume 114 pl
dc.description.number 3 pl
dc.identifier.doi 10.1016/j.acthis.2011.04.006 pl
dc.identifier.eissn 1618-0372 pl
dc.title.journal Acta Histochemica pl
dc.language.container eng pl
dc.date.accession 2015-04-09 pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2012 A]: 15


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