Angiopoietin-2 is an early indicator of acute pancreatic-renal syndrome in patients with acute pancreatitis

doi:10.1155/2016/5780903

Angiopoietin-2 is an early indicator of acute pancreatic-renal syndrome in patients with acute pancreatitis

Communities & Collections

pcg.skipToMenu

Angiopoietin-2 is an early indicator of acute pancreatic-renal syndrome in patients with acute pancreatitis

View Usage Statistics

Bibliographic description

punktacja MEiN [2016 A]: 30

title:	Angiopoietin-2 is an early indicator of acute pancreatic-renal syndrome in patients with acute pancreatitis
author:	Sporek Mateusz , Dumnicka Paulina , Gala-Bladzinska Agnieszka, Ceranowicz Piotr , Warzecha Zygmunt , Dembiński Artur , Stępień Ewa , Walocha Jerzy , Drożdż Ryszard , Kuźniewski Marek , Kuśnierz-Cabala Beata
journal title:	Mediators of Inflammation
volume:	2016
date of publication :	2016
article ID:	5780903
ISSN:	0962-9351
eISSN:	1466-1861
DOI:	10.1155/2016/5780903
language:	English
journal language:	English
abstract in English:	Within the first week of the disease, acute kidney injury (AKI) is among the most common causes of mortality in acute pancreatitis (AP). Recently, serum angiopoietin-2 (Ang-2) has been associated with hyperdynamic state of the systemic circulation. The aim of this study was to examine the associations between Ang-2 and the clinical AP severity during the first 72 hours of the disease, and organ disfunction, including AKI. Methods. Study included patients admitted to the surgery ward, diagnosed with AP. AKI was diagnosed according to KDIGO guidelines and renal failure according to modified Marshall scoring system. Ang-2 was determined in serum with ELISA. Results. AP was classified as mild (MAP) in 71% of patients, moderately severe (MSAP) in 22%, and severe (SAP) in 8%. During the first 72 hours of AP, 11 patients developed AKI and 6 developed renal failure. Ang-2 at 24, 48, and 72 hours following the onset of AP symptoms significantly predicted SAP and MSAP, as well as AKI and renal failure. Also, Ang-2 significantly correlated with acute phase proteins as well as with the indicators of renal disfunction. Conclusions. Serum Ang-2 may be a relevant predictor of AP severity, in particular of the development of AP-renal syndrome.
departmental parameterization:	30
affiliation:	Wydział Lekarski : Zakład Diagnostyki, Wydział Lekarski : Klinika Nefrologii, Wydział Farmaceutyczny : Zakład Diagnostyki Medycznej, Wydział Fizyki, Astronomii i Informatyki Stosowanej : Instytut Fizyki im. Mariana Smoluchowskiego, Wydział Lekarski : Zakład Fizjologii Klinicznej, Wydział Lekarski : Zakład Anatomii
type:	journal article
subtype:	academic paper