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Central metal determines pharmacokinetics of chlorophyll-derived xenobiotics

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Central metal determines pharmacokinetics of chlorophyll-derived xenobiotics

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dc.contributor.author Szczygieł, Małgorzata [SAP13902664] pl
dc.contributor.author Urbańska, Krystyna [SAP11009894] pl
dc.contributor.author Jurecka, Patrycja pl
dc.contributor.author Stawoska, Iwona pl
dc.contributor.author Stochel, Grażyna [SAP11011061] pl
dc.contributor.author Fiedor, Leszek [SAP11012795] pl
dc.date.accessioned 2015-01-29T11:47:11Z
dc.date.available 2015-01-29T11:47:11Z
dc.date.issued 2008 pl
dc.identifier.issn 0022-2623 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2813
dc.language eng pl
dc.title Central metal determines pharmacokinetics of chlorophyll-derived xenobiotics pl
dc.type JournalArticle pl
dc.description.physical 4412-4418 pl
dc.abstract.en Chlorophyll derivatives are potentially dangerous xenobiotics of dietary origin. The interactions of water- soluble derivatives of chlorophyll a with the animal organism were investigated using chlorophyllide a and its Zn-substituted analogue as model xenobiotics. The chlorophyllides were administered to tumor-bearing mice and their uptake, distribution, and clearance were compared. The centrally bound metal determines important aspects of the in vivo behavior of metallochlorophyllides as xenobiotics. The uptake and clearance of chlorophyllide a were significantly faster than those of [Zn]-chlorophyllide a. Chlorophyllide a showed some tissue selectivity, while [Zn]-chlorophyllide a was uniformly distributed among tissues. Interestingly, the tissue levels of the latter compound were ten times higher than those of the Mg-derivative. These differences indicate that [Zn]-chlorophyllide a, in contrast to chlorophyllide a, is only weakly recognized by the system of active transport of xenobiotics and by enzymes involved in chlorophyll metabolism. The dependence of chlorophyllide pharmacokinetics on the central metal is of great relevance to chlorophyll- based phototherapy. pl
dc.description.volume 51 pl
dc.description.number 15 pl
dc.identifier.doi 10.1021/jm7016368 pl
dc.identifier.eissn 1520-4804 pl
dc.title.journal Journal of Medicinal Chemistry pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Fizjologii i Biochemii Roślin pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki pl
dc.affiliation Wydział Chemii : Zakład Chemii Nieorganicznej pl
dc.subtype Article pl


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