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Restricted myogenic potential of mesenchymal stromal cells isolated from umbilical cord

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Restricted myogenic potential of mesenchymal stromal cells isolated from umbilical cord

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dc.contributor.author Grabowska, Iwona pl
dc.contributor.author Brzóska, Edyta pl
dc.contributor.author Gawrysiak, Agnieszka pl
dc.contributor.author Stremińska, Władysława pl
dc.contributor.author Moraczewski, Jerzy pl
dc.contributor.author Polański, Zbigniew [SAP11012133] pl
dc.contributor.author Hoser, Grażyna pl
dc.contributor.author Kawiak, Jerzy pl
dc.contributor.author Machaj, Eugeniusz K. pl
dc.contributor.author Pojda, Zygmunt pl
dc.contributor.author Ciemerych, Maria A. pl
dc.date.accessioned 2016-06-14T18:19:04Z
dc.date.available 2016-06-14T18:19:04Z
dc.date.issued 2012 pl
dc.identifier.issn 0963-6897 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/27990
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Restricted myogenic potential of mesenchymal stromal cells isolated from umbilical cord pl
dc.type JournalArticle pl
dc.description.physical 1711-1726 pl
dc.abstract.en Nonhematopoietic cord blood cells and mesenchymal cells of umbilical cord Wharton's jelly have been shown to be able to differentiate into various cell types. Thus, as they are readily available and do not raise any ethical issues, these cells are considered to be a potential source of material that can be used in regenerative medicine. In our previous study, we tested the potential of whole mononucleated fraction of human umbilical cord blood cells and showed that they are able to participate in the regeneration of injured mouse skeletal muscle. In the current study, we focused at the umbilical cord mesenchymal stromal cells isolated from Wharton's jelly. We documented that limited fraction of these cells express markers of pluripotent and myogenic cells. Moreover, they are able to undergo myogenic differentiation in vitro, as proved by coculture with C2C12 myoblasts. They also colonize injured skeletal muscle and, with low frequency, participate in the formation of new muscle fibers. Pretreatment of Wharton's jelly mesenchymal stromal cells with SDF-1 has no impact on their incorporation into regenerating muscle fibers but significantly increased muscle mass. As a result, transplantation of mesenchymal stromal cells enhances the skeletal muscle regeneration. pl
dc.subject.en skeletal muscle regeneration pl
dc.subject.en stem cells pl
dc.subject.en human umbilical cord pl
dc.subject.en Wharton's jelly pl
dc.subject.en mouse pl
dc.description.volume 21 pl
dc.description.number 8 pl
dc.identifier.doi 10.3727/096368912x640493 pl
dc.identifier.eissn 1555-3892 pl
dc.title.journal Cell Transplantation pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
.pointsMNiSW [2012 A]: 40


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