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Prenatal exposure to antiandrogen flutamide affects androgen receptor (AR) expression in postnatal ovarian development in pig

Prenatal exposure to antiandrogen flutamide affects ...

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dc.contributor.author Grzesiak, Małgorzata [SAP13905673] pl
dc.contributor.author Wieciech, Iwona [USOS39252] pl
dc.contributor.author Węgrzyn, Paulina [SAP11019019] pl
dc.contributor.author Słomczyńska, Maria [SAP11008586] pl
dc.date.accessioned 2016-06-13T09:55:04Z
dc.date.available 2016-06-13T09:55:04Z
dc.date.issued 2012 pl
dc.identifier.issn 0015-5497 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/27904
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Prenatal exposure to antiandrogen flutamide affects androgen receptor (AR) expression in postnatal ovarian development in pig pl
dc.type JournalArticle pl
dc.description.physical 27-33 pl
dc.description.additional Małgorzata Grzesiak podpisana: Małgorzata Durlej pl
dc.identifier.weblink http://www.isez.pan.krakow.pl/journals/folia/pdf/60(1-2)/60(1-2)_05.pdf pl
dc.abstract.en The following study was undertaken to localize androgen receptors (ARs) in various structures of the porcine ovary after prenatal exposure to antiandrogen flutamide. In wet. treatment by antiandrogens may have adverse effects on reproductive function in immature and adult animals. Flutamide was injected into pregnant swines between days 20 and 28 (GD20) or 80 to 88 (GD80) of gestation. The ovaries were collected from treated animals and from control ones (non-treated) at two different points of development: from immature and adult pigs. Immunoexpression of AR was determined for preantral and antral follicles and for stroma cells. Immunostaining showed that AR expression in immature animals was unaffected in the primary follicles, while in the preantral and antral follicles the AR level fluctuated depending on day of treatment as well as on analyzed tissue. In adult animals, the immunoexpression of AR slightly decreased in antral follicles independently on the day of flutamide treatment. Therefore. AR expression in postnatal life may be affected by in utero exposure to antiandrogen flutamide. pl
dc.subject.en androgen receptor pl
dc.subject.en flutamide pl
dc.subject.en pig pl
dc.subject.en ovarian development pl
dc.description.volume 60 pl
dc.description.number 1-2 pl
dc.identifier.doi 10.3409/fb60_1-2.27-33 pl
dc.identifier.eissn 1734-9168 pl
dc.title.journal Folia Biologica pl
dc.language.container eng pl
dc.date.accession 2018-04-19 pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2012 A]: 15


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa