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Daily coordination of orexinergic gating in the rat superior colliculus : implications for intrinsic clock activities in the visual system

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Daily coordination of orexinergic gating in the rat superior colliculus : implications for intrinsic clock activities in the visual system

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dc.contributor.author Chrobok, Łukasz [SAP14013048] pl
dc.contributor.author Jęczmień-Łazur, Jagoda [SAP14018552] pl
dc.contributor.author Bubka, Monika [SAP12020002] pl
dc.contributor.author Pradel, Kamil [USOS147120] pl
dc.contributor.author Klekocinska, Aleksandra pl
dc.contributor.author Klich, Jasmin Daniela pl
dc.contributor.author Rahim, Amalia Ridla pl
dc.contributor.author Myung, Jihwan pl
dc.contributor.author Kępczyński, Mariusz [SAP11015411] pl
dc.contributor.author Lewandowski, Marian [SAP11009721] pl
dc.date.accessioned 2021-09-23T10:49:12Z
dc.date.available 2021-09-23T10:49:12Z
dc.date.issued 2021 pl
dc.identifier.issn 0892-6638 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/279038
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/pl/legalcode *
dc.title Daily coordination of orexinergic gating in the rat superior colliculus : implications for intrinsic clock activities in the visual system pl
dc.type JournalArticle pl
dc.abstract.en The orexinergic system delivers excitation for multiple brain centers to facilitate behavioral arousal, with its malfunction resulting in narcolepsy, somnolence, and notably, visual hallucinations. Since the circadian clock underlies the daily arousal, a timed coordination is expected between the orexin system and its tar get subcortical visual system, including the superior colliculus (SC). Here, we use a combination of electrophysiological, immunohistochemical, and molecu lar approaches across 24 h, together with the neuronal tract-tracing methods to investigate the daily coordination between the orexin system and the rodent SC. Higher orexinergic input was found to occur nocturnally in the superficial layers of the SC, in time for nocturnal silencing of spontaneous firing in this visual brain area. We identify autonomous daily and circadian expression of clock genes in the SC, which may underlie these day–night changes. Additionally, we establish the lateral hypothalamic origin of the orexin innervation to the SC and that the SC neurons robustly respond to orexin A via $OX_{2}$ receptor in both excitatory and $GABA_{A}$ receptor-dependent inhibitory manners. Together, our evidence eluci dates the combination of intrinsic and extrinsic clock mechanisms that shape the daily function of the visual layers of the SC. pl
dc.subject.en circadian clock pl
dc.subject.en multi- electrode array pl
dc.subject.en orexin pl
dc.subject.en superior colliculus pl
dc.subject.en visual system pl
dc.description.volume 35 pl
dc.description.number 10 pl
dc.identifier.doi 10.1096/fj.202100779RR pl
dc.identifier.eissn 1530-6860 pl
dc.title.journal The FASEB Journal pl
dc.language.container eng pl
dc.affiliation Wydział Biologii : Instytut Zoologii i Badań Biomedycznych pl
dc.affiliation Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii pl
dc.affiliation Jagiellonian Interdisciplinary PhD Programme pl
dc.subtype Article pl
dc.identifier.articleid e21930 pl
dc.rights.original CC-BY-NC; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / O pl
.pointsMNiSW [2021 A]: 140


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa