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Temperature dependence of the interaction of prazosin with lipid Langmuir monolayers

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Temperature dependence of the interaction of prazosin with lipid Langmuir monolayers

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dc.contributor.author Gzyl-Malcher, Barbara [SAP11015978] pl
dc.contributor.author Handzlik, Jadwiga [SAP20001450] pl
dc.contributor.author Klekowska, Ewelina pl
dc.date.accessioned 2015-01-23T13:31:05Z
dc.date.available 2015-01-23T13:31:05Z
dc.date.issued 2013 pl
dc.identifier.issn 0927-7765 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2716
dc.language eng pl
dc.title Temperature dependence of the interaction of prazosin with lipid Langmuir monolayers pl
dc.type JournalArticle pl
dc.description.physical 171-176 pl
dc.abstract.en The influence of temperature on membrane–prazosin interactions was studied. Prazosin, a quinazoline derivative of 2-furoylpiperazine, is a classic antihypertensive and antiarrhythmic drug. A mixed cholesterol/phospholipid monolayer at the water/air interface was employed as a simplified biomembrane model. Brewster angle microscopy (BAM) was used to visualize the monolayer morphology. It was found that prazosin penetrates Langmuir monolayers and modifies the interactions between membrane components, causing monolayer fluidization. An increase in temperature facilitates penetration of prazosin into the monolayers. Prazosin interacts preferentially with phosphatidylcholine and modifies the morphology of the condensed phase domains of DPPC. In the presence of prazosin, monolayers collapse at lower surface pressures. The difference between the collapse pressures of monolayers on water with and without prazosin increases with temperature. pl
dc.subject.en Langmuir monolayer pl
dc.subject.en phospholipid pl
dc.subject.en cholesterol pl
dc.subject.en drug pl
dc.subject.en compressibility pl
dc.description.volume 112 pl
dc.description.points 30 pl
dc.identifier.doi 10.1016/j.colsurfb.2013.07.030 pl
dc.identifier.eissn 1873-4367 pl
dc.title.journal Colloids and Surfaces. B, Biointerfaces pl
dc.language.container eng pl
dc.affiliation Wydział Farmaceutyczny : Zakład Technologii i Biotechnologii Środków Leczniczych pl
dc.affiliation Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii pl
dc.subtype Article pl
dc.rights.original bez licencji pl
dc.cm.id 59899
.pointsMNiSW [2013 A]: 30


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