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An insight into the stages of ion leakage during red blood cell storage

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An insight into the stages of ion leakage during red blood cell storage

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dc.contributor.author Zimna, Anna pl
dc.contributor.author Kaczmarska, Magdalena [SAP14033414] pl
dc.contributor.author Szczęsny-Małysiak, Ewa [SAP14014326] pl
dc.contributor.author Wajda, Aleksandra [SAP14037181] pl
dc.contributor.author Bułat, Katarzyna [SAP14016538] pl
dc.contributor.author Alcicek, Fatih [USOS283539] pl
dc.contributor.author Zygmunt, Małgorzata [SAP20002109] pl
dc.contributor.author Sacha, Tomasz [SAP20001218] pl
dc.contributor.author Marzec, Katarzyna M. [SAP14003458] pl
dc.coverage.temporal 2020-07-01 – 2021-01-29 pl
dc.date.accessioned 2021-03-10T08:29:26Z
dc.date.available 2021-03-10T08:29:26Z
dc.date.issued 2021 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/266962
dc.description.sponsorship National Centre for Research and Development pl
dc.language eng pl
dc.relation Concept : 10.26106/yneb-wd27 pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/pl/legalcode *
dc.title An insight into the stages of ion leakage during red blood cell storage pl
dc.type ResearchData pl
dc.description.version 1 pl
dc.pubinfo Kraków : Repozytorium Uniwersytetu Jagiellońskiego pl
dc.description.additional Data 1. AFM data of red blood cell (RBC) changes during 6 weeks storage; Data 2. Ion concentration and blood gases parameters changes observed in the packed RBC during 6 weeks storage; Data 3. Heamotological and biochemical parameters observed in the packed RBC during 6 weeks storage pl
dc.abstract.en Packed red blood cells (pRBCs), the most commonly transfused blood product, are exposed to environmental disruptions during storage in blood banks. In this study, temporal sequence of changes in the ion exchange in pRBCs. Standard techniques commonly used in electrolyte measurements were implemented. The relationship between ion exchange and red blood cells (RBCs) morphology was assessed with use of atomic force microscopy with reference to morphological parameters. Variations observed in the Na+, K+, Cl-, H+, HCO3−, and lactate ions concentration show a complete picture of singly-charged ion changes in pRBCs during storage. Correlation between the rate of ion changes and blood group type, regarding the limitations of our research, suggested, that group 0 is the most sensitive to the time-dependent ionic changes. Additionally, the impact of irreversible changes in ion exchange on the RBCs membrane was observed in nanoscale. Results demonstrate that the level of ion leakage that leads to destructive alterations in biochemical and morphological properties of pRBCs depend on the storage timepoint. pl
dc.identifier.doi 10.26106/bwv5-gb97 pl
dc.affiliation Pion Prorektora ds. badań naukowych : Jagiellońskie Centrum Rozwoju Leków pl
dc.affiliation Wydział Lekarski : Klinika Hematologii pl
dc.affiliation Wydział Farmaceutyczny : Zakład Wstępnych Badań Farmakologicznych pl
dc.affiliation Szkoła Doktorska Nauk Ścisłych i Przyrodniczych pl
dc.subtype Collection pl
dc.description.granttitle LIDER pl
dc.description.grantnumber LIDER/13/0076/L-8/16/NCBR/2017 pl


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa