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Hydrogen sulfide formation in experimental model of acute pancreatitis

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Hydrogen sulfide formation in experimental model of acute pancreatitis

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dc.contributor.author Bronowicka-Adamska, Patrycja [SAP20008362] pl
dc.contributor.author Hutsch, Tomasz pl
dc.contributor.author Gawryś-Kopczyńska, Marta pl
dc.contributor.author Maksymiuk, Klaudia pl
dc.contributor.author Wróbel, Maria [SAP20000503] pl
dc.date.accessioned 2020-12-02T10:25:16Z pl
dc.date.available 2020-12-02T10:25:16Z pl
dc.date.issued 2019 pl
dc.identifier.issn 0001-527X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/256900
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-sa/4.0/pl/legalcode *
dc.title Hydrogen sulfide formation in experimental model of acute pancreatitis pl
dc.type JournalArticle pl
dc.description.physical 611-618 pl
dc.identifier.weblink https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2900 pl
dc.abstract.en Acute pancreatitis (AP) is a disease defined as acute or chronic inflammatory process of the pancreas characterized by premature activation of digestive enzymes within the pancreatic acinar cells and causing pancreatic auto-digestion. In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta-synthase (CBS), gammacystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST). In the mitochondria, hydrogen sulfide is oxidized to sulfite, which is then converted to thiosulfate (a sulfane sulfur-containing compound) by thiosulfate sulfurtransferase (rhodanese; TST). Activity and expression of CBS, CTH, MPST, and TST have been determined in vivo in pancreas of the control rats, rats with acute pancreatitis and a sham group. Levels of low-molecular sulfur compounds, such as the reduced and oxidized glutathione, cysteine, cystine and cystathionine, were also determined. This study revealed a significant role of MPST in H2S metabolism in the pancreas. Stress caused by the surgery (sham group) and AP cause a decrease in H2S production associated with a decrease in MPST activity and expression. Markedly higher level of cysteine in the AP pancreas may be caused by a reduced rate of cysteine consumption in a reaction catalyzed by MPST, but it can also be a sign of proteolytic processes occurring in the changed tissue pl
dc.subject.en acute pancreatitis pl
dc.subject.en cystathionine-beta-synthase pl
dc.subject.en gammacystathionase pl
dc.subject.en hydrogen sulfide pl
dc.subject.en 3-mercaptopyruvate sulfurtransferase pl
dc.subject.en rhodanese pl
dc.subject.en sulfane sulfur pl
dc.description.volume 66 pl
dc.description.number 4 pl
dc.description.points 40 pl
dc.identifier.doi 10.18388/abp.2019_2900 pl
dc.identifier.eissn 1734-154X pl
dc.title.journal Acta Biochimica Polonica pl
dc.language.container eng pl
dc.date.accession 2020-06-18 pl
dc.affiliation Wydział Lekarski : Zakład Biochemii Ogólnej pl
dc.subtype Article pl
dc.rights.original CC-BY-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 97684
dc.cm.date 2020-12-02
.pointsMNiSW [2019 A]: 40


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Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa