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Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase activity? : a contribution to the ongoing discussion

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Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase activity? : a contribution to the ongoing discussion

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dc.contributor.author Bilska-Wilkosz, Anna [SAP20007242] pl
dc.contributor.author Kotańska, Magdalena [SAP20008474] pl
dc.contributor.author Górny, Magdalena [SAP20007777] pl
dc.contributor.author Filipek, Barbara [SAP20000409] pl
dc.contributor.author Iciek, Małgorzata [SAP20002496] pl
dc.date.accessioned 2020-12-02T10:22:57Z pl
dc.date.available 2020-12-02T10:22:57Z pl
dc.date.issued 2019 pl
dc.identifier.issn 0001-527X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/256877
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-sa/4.0/pl/legalcode *
dc.title Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase activity? : a contribution to the ongoing discussion pl
dc.type JournalArticle pl
dc.description.physical 627-632 pl
dc.identifier.weblink https://ojs.ptbioch.edu.pl/index.php/abp/article/view/2908 pl
dc.abstract.en The aim of the study presented here was an attempt to answer the question posed in the title: Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase (ALDH) activity? Here, we investigated the effect of administration (separately or jointly) of lipoic acid (LA), nitroglycerin (GTN), and disulfiram (DSF; an irreversible in vivo inhibitor of all ALDH isozymes (including ALDH2)), on the development of tolerance to GTN. We also assessed the total activity of ALDH in the rat liver homogenates. Our data revealed that not only DSF and GTN inhibited the total ALDH activity in the rat liver, but LA also proved to be an inhibitor of this enzyme. At the same time, the obtained results demonstrated that the GTN tolerance did not develop in GTN, DSF and LA jointly treated rats, but did develop in GTN and DSF jointly treated rats. This means that the ability of LA to prevent GTN tolerance is not associated with the total ALDH activity in the rat liver. In this context, the fact that animals jointly receiving GTN and DSF developed tolerance to GTN, and in animals that in addition to GTN and DSF also received LA such tolerance did not develop, is - in our opinion - a sufficient premise to conclude that the nitrate tolerance certainly is not caused by a decrease in the activity of any of the ALDH isoenzymes present in the rat liver, including ALDH2. However, many questions still await an answer, including the basic one: What is the mechanism of tolerance to nitroglycerin? pl
dc.subject.en nitroglycerin tolerance pl
dc.subject.en aldehyde dehydrogenase pl
dc.subject.en disulfiram pl
dc.subject.en lipoic acid pl
dc.description.volume 66 pl
dc.description.number 4 pl
dc.description.points 40 pl
dc.identifier.doi 10.18388/abp.2019_2908 pl
dc.identifier.eissn 1734-154X pl
dc.title.journal Acta Biochimica Polonica pl
dc.language.container eng pl
dc.date.accession 2020-06-18 pl
dc.affiliation Wydział Farmaceutyczny : Studium Kształcenia Podyplomowego pl
dc.affiliation Wydział Farmaceutyczny : Zakład Wstępnych Badań Farmakologicznych pl
dc.affiliation Wydział Lekarski : Zakład Biochemii Ogólnej pl
dc.affiliation Wydział Lekarski : Zakład Chemii Fizjologicznej pl
dc.subtype Article pl
dc.rights.original CC-BY-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 97610
dc.cm.date 2020-12-02
.pointsMNiSW [2019 A]: 40


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Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Na tych samych warunkach 4.0 Międzynarodowa