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New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal

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New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal

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dc.contributor.author Kamiński, Kamil [SAP14003414] pl
dc.contributor.author Kałaska, Bartłomiej pl
dc.contributor.author Koczurkiewicz, Paulina [SAP20013377] pl
dc.contributor.author Michalik, Marta [SAP11010016] pl
dc.contributor.author Szczubiałka, Krzysztof [SAP11014318] pl
dc.contributor.author Mogielnicki, Andrzej pl
dc.contributor.author Buczko, Włodzimierz pl
dc.contributor.author Nowakowska, Maria [SAP11005597] pl
dc.date.accessioned 2015-01-15T11:08:08Z
dc.date.available 2015-01-15T11:08:08Z
dc.date.issued 2014 pl
dc.identifier.issn 2040-2503 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2565
dc.language eng pl
dc.title New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal pl
dc.type JournalArticle pl
dc.description.physical 489-495 pl
dc.abstract.en New derivatives of polyallylamine containing arginine moieties (PAH-ARG) were synthesized. The in vitro tests performed in heparinized blood plasma showed that the complexation of heparin by PAH-ARG polymers allowed the reduction of the activated partial thromboplastin time (aPTT) values to the normal level. The dose of PAH-ARG required for complete reversal of aPTT (prolonged by 1 U of heparin) was half of that required for protamine sulfate, the currently used heparin antagonist. The efficacy of these polymers in the neutralization of heparin was confirmed by in vivo tests using a rat model. PAH-ARG polymers were nontoxic to the fibroblast cells. pl
dc.description.volume 5 pl
dc.description.number 4 pl
dc.identifier.doi 10.1039/c3md00374d pl
dc.identifier.eissn 2040-2511 pl
dc.title.journal MedChemComm pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biologii Komórki pl
dc.affiliation Wydział Farmaceutyczny : Zakład Biochemii Farmaceutycznej pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2014 A]: 25


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