New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal

Bibliographic description

punktacja MEiN [2014 A]: 25

title:	New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal
author:	Kamiński Kamil , Kałaska Bartłomiej, Koczurkiewicz Paulina , Michalik Marta , Szczubiałka Krzysztof , Mogielnicki Andrzej, Buczko Włodzimierz, Nowakowska Maria
journal title:	MedChemComm
volume:	5
issue:	4
date of publication :	2014
pages:	489-495
ISSN:	2040-2503
eISSN:	2040-2511
DOI:	10.1039/c3md00374d
language:	English
journal language:	English
abstract in English:	New derivatives of polyallylamine containing arginine moieties (PAH-ARG) were synthesized. The in vitro tests performed in heparinized blood plasma showed that the complexation of heparin by PAH-ARG polymers allowed the reduction of the activated partial thromboplastin time (aPTT) values to the normal level. The dose of PAH-ARG required for complete reversal of aPTT (prolonged by 1 U of heparin) was half of that required for protamine sulfate, the currently used heparin antagonist. The efficacy of these polymers in the neutralization of heparin was confirmed by in vivo tests using a rat model. PAH-ARG polymers were nontoxic to the fibroblast cells.
affiliation:	Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii, Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biologii Komórki, Wydział Farmaceutyczny : Zakład Biochemii Farmaceutycznej
type:	journal article
subtype:	academic paper

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