The current view on biological potency of cationically modified chitosan

The current view on biological potency of cationically modified chitosan

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The current view on biological potency of cationically modified chitosan

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punktacja MEiN [2014 A]: 25

title:	The current view on biological potency of cationically modified chitosan
author:	Stefan Joanna , Lorkowska-Zawicka Barbara , Kamiński Kamil , Szczubiałka Krzysztof , Nowakowska Maria , Korbut Ryszard
journal title:	Journal of Physiology and Pharmacology
volume:	65
issue:	3
date of publication :	2014
pages:	341-347
ISSN:	0867-5910
eISSN:	1899-1505
URL:	http://www.jpp.krakow.pl/journal/archive/06_14/pdf/341_06_14_article.pdf
date accessed:	2015-01-05
language:	English
journal language:	English
abstract in English:	Chitosan is biocompatible polymer obtained from chitin, the building component of the crustacean shells. In this paper we make an attempt to review the current state of knowledge on some biological effects of chitosan in comparison with those of cationically modified chitosan, N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) that was recently synthetized by us by covalent attachment of glycidyltrimethylammonium chloride (GTMAC). Biological effects of HTCC and non-modified polymer are very similar. However, HTCC shows some unique beneficial properties which have not been found in its non-modified counterpart. One such example is that HTCC has the ability to bind heparin at physiological pH. HTCC having the degree of substitution almost 63.6% is easily absorbed within 1 hour after oral administration as found in C57BL/6j mice using FITC-labeled polymer. HTCC is distributed to lung, heart, and kidneys. HTCC stimulates and enhances blood platelet aggregation and decreases erythrocyte deformability (RBC). Moreover, HTCC seems to decrease both plasma total cholesterol level and LDL-cholesterol level in apoE-knockout mice fed with a diet containing HTCC. HTCC possibly down-regulates the HMG-CoAR mRNA level after 24 hour incubation with HepG2 cells in vitro.
keywords in English:	apoE knockout mouse, atherosclerosis, cationically modified chitosan, chitosan, heparin, hypercholesterolemia, lipid metabolism, platelet aggregation, quaternization, red blood cells deformability
departmental parameterization:	25
affiliation:	Wydział Lekarski : Zakład Farmakologii, Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii
type:	journal article
subtype:	review article