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Roxithromycin degradation by acidic hydrolysis and photocatalysis

Roxithromycin degradation by acidic hydrolysis and ...

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dc.contributor.author Kwiecień, Anna [SAP20001328] pl
dc.contributor.author Krzek, Jan [SAP20001551] pl
dc.contributor.author Żmudzki, Paweł [SAP20010962] pl
dc.contributor.author Matoga, Urszula pl
dc.contributor.author Długosz, Maciej [USOS35634] pl
dc.contributor.author Szczubiałka, Krzysztof [SAP11014318] pl
dc.contributor.author Nowakowska, Maria [SAP11005597] pl
dc.date.accessioned 2015-01-15T11:01:12Z
dc.date.available 2015-01-15T11:01:12Z
dc.date.issued 2014 pl
dc.identifier.issn 1759-9660 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2562
dc.language eng pl
dc.title Roxithromycin degradation by acidic hydrolysis and photocatalysis pl
dc.type JournalArticle pl
dc.description.physical 6414-6423 pl
dc.abstract.en The purpose of this work was to study two methods of degradation of roxithromycin: acidic hydrolysis and photocatalytic degradation under illumination with near-UV light in the presence of the TiO2 photosensitizer. For acidic degradation studies a TLC-densitometric method has been developed using TLC aluminium plates precoated with silica gel F 254 and the mobile phase composed of methanol-acetone-ammonia 25% (1:14:0.1, v/v/v) which gives compact spots for roxithromycin and its degradation products. Photocatalytic degradation studies in the presence of TiO2 were monitored by HPLC. The obtained results have shown that both methods of degradation of roxithromycin are quite efficient. Kinetics of the first order photocatalytic degradation reaction follows the Langmuir-Hinshelwood theory for photocatalytic microheterogeneous systems. The chemical structures of the degradation products obtained during acidic degradation and photocatalytic degradation were suggested based on the UPLC-MS/MS technique. The general mechanisms of both processes were proposed. pl
dc.description.volume 6 pl
dc.description.number 16 pl
dc.identifier.doi 10.1039/c4ay00708e pl
dc.identifier.eissn 1759-9679 pl
dc.title.journal Analytical Methods pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii pl
dc.affiliation Wydział Farmaceutyczny : Zakład Chemii Leków pl
dc.affiliation Wydział Farmaceutyczny : Zakład Chemii Analitycznej pl
dc.subtype Article pl
dc.rights.original bez licencji pl
dc.pbn.affiliation USOS35634:UJ.WCh; pl
.pointsMNiSW [2014 A]: 25

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