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Tumour-derived microvesicles (TMV) mimic the effect of tumour cells on monocyte subpopulations


Tumour-derived microvesicles (TMV) mimic the effect of tumour cells on monocyte subpopulations

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dc.contributor.author Baj-Krzyworzeka, Monika [SAP20002003] pl
dc.contributor.author Baran, Jarosław [SAP20001320] pl
dc.contributor.author Węglarczyk, Kazimierz [SAP20008277] pl
dc.contributor.author Szatanek, Rafał [SAP20008095] pl
dc.contributor.author Szaflarska, Anna [SAP20001888] pl
dc.contributor.author Siedlar, Maciej [SAP20001094] pl
dc.contributor.author Zembala, Marek [SAP20001083] pl
dc.date.accessioned 2020-10-20T06:28:07Z
dc.date.available 2020-10-20T06:28:07Z
dc.date.issued 2010 pl
dc.identifier.issn 0250-7005 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/248384
dc.language eng pl
dc.rights Dozwolony użytek utworów chronionych *
dc.rights.uri http://ruj.uj.edu.pl/4dspace/License/copyright/licencja_copyright.pdf *
dc.title Tumour-derived microvesicles (TMV) mimic the effect of tumour cells on monocyte subpopulations pl
dc.type JournalArticle pl
dc.description.physical 3515-3519 pl
dc.description.additional Bibliogr. s. 3518-3519 pl
dc.identifier.weblink http://ar.iiarjournals.org/content/30/9/3515.full.pdf+html pl
dc.abstract.en Background: Monocytes/macrophages may be affected by tumour cells via cell-to-cell contact, soluble factors and by tumour-derived microvesicles (TMV). Previous observations indicate that TMV interact with monocytes and alter their immunophenotype and activity. This study was designed to determine interactions of TMV with subpopulations (CD14++CD16– and CD14+CD16++) of human monocytes. Methods: Engulfment of TMV by subsets of monocytes was analysed by flow cytometry. Moreover cytokine release and production of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) by CD14++CD16– and CD14+CD16++ cells after TMV stimulation was determined. Results: It was found that TMV are engulfed more efficiently by CD14++CD16– than CD14+CD16++ cells. TMV-activated CD14++CD16– cells produce more ROI and interleukin -10 (IL-10) than CD14++CD16+. CD14+CD16++ cells following TMV stimulation showed an increased release of tumour necrosis factor alpha, IL-12p40 and RNI. Conclusion: TMV significantly modulate biological activity of monocyte subsets with a pattern similar to tumour cells. Therefore, TMV mimic the activating effect of tumour cells on monocytes as assessed by release of cytokines, ROI and RNI. pl
dc.subject.en tumour-derived microvesicles pl
dc.subject.en CD14++CD16– pl
dc.subject.en CD14+CD16++ monocyte subsets pl
dc.description.volume 30 pl
dc.description.number 9 pl
dc.description.publication 0,61 pl
dc.identifier.eissn 1791-7530 pl
dc.title.journal Anticancer Research pl
dc.language.container eng pl
dc.date.accession 2020-10-20 pl
dc.affiliation Wydział Lekarski : Instytut Pediatrii pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; po opublikowaniu; 24 pl
dc.identifier.project ROD UJ / OP pl
.pointsMNiSW [2010 A]: 20

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