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Human monocytes both enhance and inhibit the growth of human pancreatic cancer in SCID mice

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Human monocytes both enhance and inhibit the growth of human pancreatic cancer in SCID mice

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dc.contributor.author Mytar, Bożenna [SAP20008444] pl
dc.contributor.author Baj-Krzyworzeka, Monika [SAP20002003] pl
dc.contributor.author Majka, Marcin [SAP20017140] pl
dc.contributor.author Stankiewicz, Danuta pl
dc.contributor.author Zembala, Marek [SAP20001083] pl
dc.date.accessioned 2020-10-19T12:44:25Z
dc.date.available 2020-10-19T12:44:25Z
dc.date.issued 2008 pl
dc.identifier.issn 0250-7005 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/248342
dc.language eng pl
dc.rights Dozwolony użytek utworów chronionych *
dc.rights.uri http://ruj.uj.edu.pl/4dspace/License/copyright/licencja_copyright.pdf *
dc.title Human monocytes both enhance and inhibit the growth of human pancreatic cancer in SCID mice pl
dc.type JournalArticle pl
dc.description.physical 187-192 pl
dc.description.additional Bibliogr. s. 191-192 pl
dc.identifier.weblink http://ar.iiarjournals.org/content/28/3B/1927.full.pdf+html pl
dc.abstract.en Background: Monocytes/macrophages exhibit antitumour potential, but clinicopathological evidence suggests that they may both inhibit and enhance tumour growth. The purpose of this study was to determine the effect of monocytes on the growth of human pancreatic cancer (HPC-4) in severe combined immunodeficient (SCID) mice. Materials and Methods: Freshly isolated human monocytes or CD14+ cells from cocultures with tumour cells were coengrafted, at various ratios, with HPC-4 cells into SCID mice. The tumour size and angiogenesis were determined. Results: At a high ratio of monocytes to cancer cells the enhancement and, at a low ratio, the inhibition of tumour growth was observed. Multiple intratumoral applications of monocytes in large numbers also enhanced tumour growth. Deactivation of monocytes by a short pre-exposure to tumour cells in vitro before engraftment led to increased tumour growth. Monocytes used in large numbers and deactivated monocytes in low doses enhanced tumour-induced angiogenesis. Conclusion: Monocytes may both facilitate and suppress the growth of human tumours in SCID mice and both the number of monocytes, as well as the state of monocyte deactivation are critical for the final outcome of monocyte-tumour interactions. pl
dc.subject.en monocytes pl
dc.subject.en tumour growth pl
dc.subject.en cytokines pl
dc.subject.en angiogenesis pl
dc.description.volume 28 pl
dc.description.number 1A pl
dc.description.publication 0,62 pl
dc.identifier.eissn 1791-7530 pl
dc.title.journal Anticancer Research pl
dc.language.container eng pl
dc.date.accession 2020-10-19 pl
dc.affiliation Wydział Lekarski : Instytut Pediatrii pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; po opublikowaniu; 24 pl
dc.identifier.project ROD UJ / OP pl


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